Lacrimal and salivary gland inflammation in the C3H/lpr autoimmune strain mouse

A potential mode for Sjogren's syndrome

B. C. Johnson, J. I. Morton, Dennis Trune

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Sjogren's syndrome is an autoimmune inflammatory disease that affects the lacrimal and salivary glands. To identify a potential animal model for study of Sjogren's syndrome, an evaluation was made of lacrimal and salivary glands in the C3H/lpr autoimmune strain mouse at ages before (2 months) and after (5 months) systemic autoimmune disease onset at 3 to 4 months. Quantitative and qualitative analyses of C3H/lpr lacrimal and salivary (parotid, submandibular, and sublingual) gland histopathology were performed using age- matched C3H/HeJ nonautoimmune mice to control for inflammation of nonautoimmune origin. No lacrimal or salivary gland inflammation was seen in either of the strains at 2 months of age and measures of systemic autoimmune disease were negative. At 5 months of age, the nonautoimmune C3H/HeJ controls showed a slight increase in lacrimal gland inflammation, but this was not significantly different from the 2 month old controls. A significant increase in lacrimal gland inflammation was found in the 5 month old C3H/lpr autoimmune mice in a histologic pattern similar to that of Sjogren's syndrome in human beings. Furthermore, the degree of inflammation was positively correlated with serum immune complexes and spleen weight. Sporadic inflammation of the submandibular gland was seen in both autoimmune and control mice, but this was neither statistically significant nor correlated with measures of autoimmunity. No significant inflammation was seen in the parotid or sublingual glands.

Original languageEnglish (US)
Pages (from-to)394-399
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume106
Issue number4
StatePublished - 1992

Fingerprint

Sialadenitis
Lacrimal Apparatus
Sjogren's Syndrome
Inflammation
Sublingual Gland
Autoimmune Diseases
Submandibular Gland
Salivary Glands
Parotid Gland
Antigen-Antibody Complex
Autoimmunity
Tears
Spleen
Animal Models
Weights and Measures
Serum

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Lacrimal and salivary gland inflammation in the C3H/lpr autoimmune strain mouse : A potential mode for Sjogren's syndrome. / Johnson, B. C.; Morton, J. I.; Trune, Dennis.

In: Otolaryngology - Head and Neck Surgery, Vol. 106, No. 4, 1992, p. 394-399.

Research output: Contribution to journalArticle

@article{b741611ee4964ef281573ca2abf3db5b,
title = "Lacrimal and salivary gland inflammation in the C3H/lpr autoimmune strain mouse: A potential mode for Sjogren's syndrome",
abstract = "Sjogren's syndrome is an autoimmune inflammatory disease that affects the lacrimal and salivary glands. To identify a potential animal model for study of Sjogren's syndrome, an evaluation was made of lacrimal and salivary glands in the C3H/lpr autoimmune strain mouse at ages before (2 months) and after (5 months) systemic autoimmune disease onset at 3 to 4 months. Quantitative and qualitative analyses of C3H/lpr lacrimal and salivary (parotid, submandibular, and sublingual) gland histopathology were performed using age- matched C3H/HeJ nonautoimmune mice to control for inflammation of nonautoimmune origin. No lacrimal or salivary gland inflammation was seen in either of the strains at 2 months of age and measures of systemic autoimmune disease were negative. At 5 months of age, the nonautoimmune C3H/HeJ controls showed a slight increase in lacrimal gland inflammation, but this was not significantly different from the 2 month old controls. A significant increase in lacrimal gland inflammation was found in the 5 month old C3H/lpr autoimmune mice in a histologic pattern similar to that of Sjogren's syndrome in human beings. Furthermore, the degree of inflammation was positively correlated with serum immune complexes and spleen weight. Sporadic inflammation of the submandibular gland was seen in both autoimmune and control mice, but this was neither statistically significant nor correlated with measures of autoimmunity. No significant inflammation was seen in the parotid or sublingual glands.",
author = "Johnson, {B. C.} and Morton, {J. I.} and Dennis Trune",
year = "1992",
language = "English (US)",
volume = "106",
pages = "394--399",
journal = "Otolaryngology - Head and Neck Surgery (United States)",
issn = "0194-5998",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Lacrimal and salivary gland inflammation in the C3H/lpr autoimmune strain mouse

T2 - A potential mode for Sjogren's syndrome

AU - Johnson, B. C.

AU - Morton, J. I.

AU - Trune, Dennis

PY - 1992

Y1 - 1992

N2 - Sjogren's syndrome is an autoimmune inflammatory disease that affects the lacrimal and salivary glands. To identify a potential animal model for study of Sjogren's syndrome, an evaluation was made of lacrimal and salivary glands in the C3H/lpr autoimmune strain mouse at ages before (2 months) and after (5 months) systemic autoimmune disease onset at 3 to 4 months. Quantitative and qualitative analyses of C3H/lpr lacrimal and salivary (parotid, submandibular, and sublingual) gland histopathology were performed using age- matched C3H/HeJ nonautoimmune mice to control for inflammation of nonautoimmune origin. No lacrimal or salivary gland inflammation was seen in either of the strains at 2 months of age and measures of systemic autoimmune disease were negative. At 5 months of age, the nonautoimmune C3H/HeJ controls showed a slight increase in lacrimal gland inflammation, but this was not significantly different from the 2 month old controls. A significant increase in lacrimal gland inflammation was found in the 5 month old C3H/lpr autoimmune mice in a histologic pattern similar to that of Sjogren's syndrome in human beings. Furthermore, the degree of inflammation was positively correlated with serum immune complexes and spleen weight. Sporadic inflammation of the submandibular gland was seen in both autoimmune and control mice, but this was neither statistically significant nor correlated with measures of autoimmunity. No significant inflammation was seen in the parotid or sublingual glands.

AB - Sjogren's syndrome is an autoimmune inflammatory disease that affects the lacrimal and salivary glands. To identify a potential animal model for study of Sjogren's syndrome, an evaluation was made of lacrimal and salivary glands in the C3H/lpr autoimmune strain mouse at ages before (2 months) and after (5 months) systemic autoimmune disease onset at 3 to 4 months. Quantitative and qualitative analyses of C3H/lpr lacrimal and salivary (parotid, submandibular, and sublingual) gland histopathology were performed using age- matched C3H/HeJ nonautoimmune mice to control for inflammation of nonautoimmune origin. No lacrimal or salivary gland inflammation was seen in either of the strains at 2 months of age and measures of systemic autoimmune disease were negative. At 5 months of age, the nonautoimmune C3H/HeJ controls showed a slight increase in lacrimal gland inflammation, but this was not significantly different from the 2 month old controls. A significant increase in lacrimal gland inflammation was found in the 5 month old C3H/lpr autoimmune mice in a histologic pattern similar to that of Sjogren's syndrome in human beings. Furthermore, the degree of inflammation was positively correlated with serum immune complexes and spleen weight. Sporadic inflammation of the submandibular gland was seen in both autoimmune and control mice, but this was neither statistically significant nor correlated with measures of autoimmunity. No significant inflammation was seen in the parotid or sublingual glands.

UR - http://www.scopus.com/inward/record.url?scp=0026704167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026704167&partnerID=8YFLogxK

M3 - Article

VL - 106

SP - 394

EP - 399

JO - Otolaryngology - Head and Neck Surgery (United States)

JF - Otolaryngology - Head and Neck Surgery (United States)

SN - 0194-5998

IS - 4

ER -