Lack of suitability of the rabbit model for particulate uterine artery embolization

Christoph A. Binkert, Robert T. Andrews, Dusan Pavcnik, Barry Uchida, Marc Loriaux, Naoyuki Toyota, Josef Rosch

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PURPOSE: The goal of this study was to evaluate the rabbit model for studies of particulate uterine artery embolization (UAE). Rabbits were chosen because it was believed that their year-round breeding time and short duration of pregnancy would be useful in studies of fertility and pregnancy after UAE. MATERIALS AND METHODS: Bilateral UAE was performed in 12 adult female New Zealand White rabbits weighing 4-5.2 kg. All animals were proven to be breeders before treatment. Each uterine artery was embolized to stasis with use of 180-300-μm polyvinyl alcohol (PVA) particles (n = 9 animals), 500-710-μm PVA particles (n = 1), or tris-acryl 500-700-μm gelatin microspheres (n = 2). RESULTS: Two rabbits died 7 days after embolization and the other 10 rabbits had to be killed because of malaise and weight loss 4-8 d after embolization. In all animals, necropsy demonstrated extensive uterine necrosis sparing only the tip of the uterine horn. CONCLUSION: Rabbits are an unsuitable model for studies of UAE with the embolic agents in clinical use.

Original languageEnglish (US)
Pages (from-to)609-612
Number of pages4
JournalJournal of Vascular and Interventional Radiology
Volume13
Issue number6
StatePublished - 2002

Fingerprint

Uterine Artery Embolization
Rabbits
Polyvinyl Alcohol
Uterine Artery
Pregnancy
Gelatin
Microspheres
Breeding
Fertility
Weight Loss
Necrosis

Keywords

  • Fibroid
  • Uterine arteries, embolization
  • Uterus, neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Lack of suitability of the rabbit model for particulate uterine artery embolization. / Binkert, Christoph A.; Andrews, Robert T.; Pavcnik, Dusan; Uchida, Barry; Loriaux, Marc; Toyota, Naoyuki; Rosch, Josef.

In: Journal of Vascular and Interventional Radiology, Vol. 13, No. 6, 2002, p. 609-612.

Research output: Contribution to journalArticle

Binkert, Christoph A. ; Andrews, Robert T. ; Pavcnik, Dusan ; Uchida, Barry ; Loriaux, Marc ; Toyota, Naoyuki ; Rosch, Josef. / Lack of suitability of the rabbit model for particulate uterine artery embolization. In: Journal of Vascular and Interventional Radiology. 2002 ; Vol. 13, No. 6. pp. 609-612.
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AU - Toyota, Naoyuki

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