Lack of suitability of the rabbit model for particulate uterine artery embolization

Christoph A. Binkert, Robert T. Andrews, Dusan Pavcnik, Barry Uchida, Marc M. Loriaux, Naoyuki Toyota, Josef Rösch

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

PURPOSE: The goal of this study was to evaluate the rabbit model for studies of particulate uterine artery embolization (UAE). Rabbits were chosen because it was believed that their year-round breeding time and short duration of pregnancy would be useful in studies of fertility and pregnancy after UAE. MATERIALS AND METHODS: Bilateral UAE was performed in 12 adult female New Zealand White rabbits weighing 4-5.2 kg. All animals were proven to be breeders before treatment. Each uterine artery was embolized to stasis with use of 180-300-μm polyvinyl alcohol (PVA) particles (n = 9 animals), 500-710-μm PVA particles (n = 1), or tris-acryl 500-700-μm gelatin microspheres (n = 2). RESULTS: Two rabbits died 7 days after embolization and the other 10 rabbits had to be killed because of malaise and weight loss 4-8 d after embolization. In all animals, necropsy demonstrated extensive uterine necrosis sparing only the tip of the uterine horn. CONCLUSION: Rabbits are an unsuitable model for studies of UAE with the embolic agents in clinical use.

Original languageEnglish (US)
Article number61655
Pages (from-to)609-612
Number of pages4
JournalJournal of Vascular and Interventional Radiology
Volume13
Issue number6
DOIs
StatePublished - Jan 1 2002

Keywords

  • Fibroid
  • Uterine arteries, embolization
  • Uterus, neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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