Lack of platelet monoamine oxidase activity in cebus monkeys (Cebus albifrons)

Ron Heintz; Mary Ann Richardson; Autour S. Perumal; Daniel E. Casey

doi:10.1016/0742-8413(89)90257-0

Lack of platelet monoamine oxidase activity in cebus monkeys (Cebus albifrons)

Ron Heintz, Mary Ann Richardson, Autour S. Perumal, Daniel E. Casey

Research output: Contribution to journal › Article › peer-review

Abstract

1. Recent evidence suggests that monoamine oxidase (MAO) plays an important role modulating the extrapyramidal syndromes produced by neuroleptic drugs in both human and nonhuman primates. 2. To evaluate the possibility of using peripheral blood platelet MAO-B levels as indices of central nervous system MAO-B effects, we measured platelet MAO-B levels in Cebus monkeys that were previously tested with neuroleptics (N = 36) or drug naive (N = 6). 3. No platelet MAO-B was consistently detectable in these blood samples. 4. Thus platelet measures of MAO-B do not reliably reflect brain MAO-B function in nonhuman primates and do not offer a useful model for studying blood-brain MAO-B relationships.

Original language	English (US)
Pages (from-to)	421-423
Number of pages	3
Journal	Comparative Biochemistry and Physiology. Part C, Comparative
Volume	93
Issue number	2
DOIs	https://doi.org/10.1016/0742-8413(89)90257-0
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Immunology
Pharmacology

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title = "Lack of platelet monoamine oxidase activity in cebus monkeys (Cebus albifrons)",

abstract = "1. Recent evidence suggests that monoamine oxidase (MAO) plays an important role modulating the extrapyramidal syndromes produced by neuroleptic drugs in both human and nonhuman primates. 2. To evaluate the possibility of using peripheral blood platelet MAO-B levels as indices of central nervous system MAO-B effects, we measured platelet MAO-B levels in Cebus monkeys that were previously tested with neuroleptics (N = 36) or drug naive (N = 6). 3. No platelet MAO-B was consistently detectable in these blood samples. 4. Thus platelet measures of MAO-B do not reliably reflect brain MAO-B function in nonhuman primates and do not offer a useful model for studying blood-brain MAO-B relationships.",

author = "Ron Heintz and Richardson, {Mary Ann} and Perumal, {Autour S.} and Casey, {Daniel E.}",

year = "1989",

doi = "10.1016/0742-8413(89)90257-0",

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pages = "421--423",

journal = "Comparative Biochemistry and Physiology. Part C, Comparative",

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T1 - Lack of platelet monoamine oxidase activity in cebus monkeys (Cebus albifrons)

AU - Heintz, Ron

AU - Richardson, Mary Ann

AU - Perumal, Autour S.

AU - Casey, Daniel E.

PY - 1989

Y1 - 1989

N2 - 1. Recent evidence suggests that monoamine oxidase (MAO) plays an important role modulating the extrapyramidal syndromes produced by neuroleptic drugs in both human and nonhuman primates. 2. To evaluate the possibility of using peripheral blood platelet MAO-B levels as indices of central nervous system MAO-B effects, we measured platelet MAO-B levels in Cebus monkeys that were previously tested with neuroleptics (N = 36) or drug naive (N = 6). 3. No platelet MAO-B was consistently detectable in these blood samples. 4. Thus platelet measures of MAO-B do not reliably reflect brain MAO-B function in nonhuman primates and do not offer a useful model for studying blood-brain MAO-B relationships.

AB - 1. Recent evidence suggests that monoamine oxidase (MAO) plays an important role modulating the extrapyramidal syndromes produced by neuroleptic drugs in both human and nonhuman primates. 2. To evaluate the possibility of using peripheral blood platelet MAO-B levels as indices of central nervous system MAO-B effects, we measured platelet MAO-B levels in Cebus monkeys that were previously tested with neuroleptics (N = 36) or drug naive (N = 6). 3. No platelet MAO-B was consistently detectable in these blood samples. 4. Thus platelet measures of MAO-B do not reliably reflect brain MAO-B function in nonhuman primates and do not offer a useful model for studying blood-brain MAO-B relationships.

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Lack of platelet monoamine oxidase activity in cebus monkeys (Cebus albifrons)

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