Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact

Yali Jia, Lin An, Ruikang K. Wang

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We demonstrate for the first time that the detailed blood flow distribution within intracranial dura mater and cortex can be visualized by an ultrahigh sensitive optical microangiography (UHS-OMAG). The study uses an UHS-OMAG system operating at 1310 nm with an imaging speed at 150 frames per second that requires ∼10 s to complete one 3-D scan of ∼2.5×2.5 mm 2. The system is sensitive to blood flow with a velocity ranging from ∼4 μm/s to ∼23 mm/ s. We show superior performance of UHS-OMAG in providing functional images of capillary level microcirculation within meninges in mice with the cranium left intact, the results of which correlate well with the standard dural histopathology.

Original languageEnglish (US)
Article number030510
JournalJournal of biomedical optics
Volume15
Issue number3
DOIs
StatePublished - May 2010

Keywords

  • Blood flow
  • Meningeal blood vessel network
  • Microcirculation
  • Optical microangiography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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