Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact

Jia Yali, Lin An, Ruikang K. Wang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We demonstrate for the first time that the detailed blood flow distribution within intracranial dura mater and cortex can be visualized by an ultrahigh sensitive optical microangiography (UHS-OMAG). The study uses an UHS-OMAG system operating at 1310 nm with an imaging speed at 150 frames per second that requires ∼10 s to complete one 3-D scan of ∼2.5×2.5 mm 2. The system is sensitive to blood flow with a velocity ranging from ∼4 μm/s to ∼23 mm/ s. We show superior performance of UHS-OMAG in providing functional images of capillary level microcirculation within meninges in mice with the cranium left intact, the results of which correlate well with the standard dural histopathology.

Original languageEnglish (US)
Article number030510
JournalJournal of Biomedical Optics
Volume15
Issue number3
DOIs
StatePublished - May 2010

Fingerprint

cranium
Microcirculation
cortexes
blood flow
mice
Labels
Blood
Imaging techniques
Optical systems
flow distribution

Keywords

  • Blood flow
  • Meningeal blood vessel network
  • Microcirculation
  • Optical microangiography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact. / Yali, Jia; An, Lin; Wang, Ruikang K.

In: Journal of Biomedical Optics, Vol. 15, No. 3, 030510, 05.2010.

Research output: Contribution to journalArticle

@article{f11ebec5bb834a59a75f764af8f0c181,
title = "Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact",
abstract = "We demonstrate for the first time that the detailed blood flow distribution within intracranial dura mater and cortex can be visualized by an ultrahigh sensitive optical microangiography (UHS-OMAG). The study uses an UHS-OMAG system operating at 1310 nm with an imaging speed at 150 frames per second that requires ∼10 s to complete one 3-D scan of ∼2.5×2.5 mm 2. The system is sensitive to blood flow with a velocity ranging from ∼4 μm/s to ∼23 mm/ s. We show superior performance of UHS-OMAG in providing functional images of capillary level microcirculation within meninges in mice with the cranium left intact, the results of which correlate well with the standard dural histopathology.",
keywords = "Blood flow, Meningeal blood vessel network, Microcirculation, Optical microangiography",
author = "Jia Yali and Lin An and Wang, {Ruikang K.}",
year = "2010",
month = "5",
doi = "10.1117/1.3432654",
language = "English (US)",
volume = "15",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "3",

}

TY - JOUR

T1 - Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact

AU - Yali, Jia

AU - An, Lin

AU - Wang, Ruikang K.

PY - 2010/5

Y1 - 2010/5

N2 - We demonstrate for the first time that the detailed blood flow distribution within intracranial dura mater and cortex can be visualized by an ultrahigh sensitive optical microangiography (UHS-OMAG). The study uses an UHS-OMAG system operating at 1310 nm with an imaging speed at 150 frames per second that requires ∼10 s to complete one 3-D scan of ∼2.5×2.5 mm 2. The system is sensitive to blood flow with a velocity ranging from ∼4 μm/s to ∼23 mm/ s. We show superior performance of UHS-OMAG in providing functional images of capillary level microcirculation within meninges in mice with the cranium left intact, the results of which correlate well with the standard dural histopathology.

AB - We demonstrate for the first time that the detailed blood flow distribution within intracranial dura mater and cortex can be visualized by an ultrahigh sensitive optical microangiography (UHS-OMAG). The study uses an UHS-OMAG system operating at 1310 nm with an imaging speed at 150 frames per second that requires ∼10 s to complete one 3-D scan of ∼2.5×2.5 mm 2. The system is sensitive to blood flow with a velocity ranging from ∼4 μm/s to ∼23 mm/ s. We show superior performance of UHS-OMAG in providing functional images of capillary level microcirculation within meninges in mice with the cranium left intact, the results of which correlate well with the standard dural histopathology.

KW - Blood flow

KW - Meningeal blood vessel network

KW - Microcirculation

KW - Optical microangiography

UR - http://www.scopus.com/inward/record.url?scp=79958071092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958071092&partnerID=8YFLogxK

U2 - 10.1117/1.3432654

DO - 10.1117/1.3432654

M3 - Article

VL - 15

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 3

M1 - 030510

ER -