KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors: Relevance of concomitant phosphatidylinositol 3-kinase/AKT dysregulation

César Serrano, Yuexiang Wang, Adrián Mariño-Enríquez, Jen Chieh Lee, Gloria Ravegnini, Jeffrey A. Morgan, Monica M. Bertagnolli, Carol Beadling, George D. Demetri, Christopher Corless, Michael Heinrich, Jonathan A. Fletcher

Research output: Contribution to journalArticle

22 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)e93-e96
JournalJournal of Clinical Oncology
Volume33
Issue number22
DOIs
StatePublished - Aug 1 2015

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Neoplasm Drug Resistance
Proto-Oncogene Proteins
Piperazines
Benzamides
TOR Serine-Threonine Kinases
Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-kit
ras Proteins
Pyrimidines
Proto-Oncogene Proteins c-akt
Gastrointestinal Stromal Tumors
Isoleucine
Threonine
Protein Kinase Inhibitors
DNA Sequence Analysis
Antineoplastic Agents
Glycine
Stomach Neoplasms
Arginine
Signal Transduction

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors : Relevance of concomitant phosphatidylinositol 3-kinase/AKT dysregulation. / Serrano, César; Wang, Yuexiang; Mariño-Enríquez, Adrián; Lee, Jen Chieh; Ravegnini, Gloria; Morgan, Jeffrey A.; Bertagnolli, Monica M.; Beadling, Carol; Demetri, George D.; Corless, Christopher; Heinrich, Michael; Fletcher, Jonathan A.

In: Journal of Clinical Oncology, Vol. 33, No. 22, 01.08.2015, p. e93-e96.

Research output: Contribution to journalArticle

Serrano, César ; Wang, Yuexiang ; Mariño-Enríquez, Adrián ; Lee, Jen Chieh ; Ravegnini, Gloria ; Morgan, Jeffrey A. ; Bertagnolli, Monica M. ; Beadling, Carol ; Demetri, George D. ; Corless, Christopher ; Heinrich, Michael ; Fletcher, Jonathan A. / KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors : Relevance of concomitant phosphatidylinositol 3-kinase/AKT dysregulation. In: Journal of Clinical Oncology. 2015 ; Vol. 33, No. 22. pp. e93-e96.
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