Kinetic analysis of platelet monoamine oxidase in chronic schizophrenia

Alan Breier, Robert Hitzemann, Jack Hirschowitz, David L. Garver

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Km and Vmax values for platelet monoamine oxidase (MAO) were determined in 16 chronic schizophrenics and 18 controls utilizing three substrates, tyramine (TYR), benzylamine (BZ), and phenylethylamine (PEA). In the chronic schizophrenics decreased Km and Vmax values were found for TYR and BZ but not PEA. When prior neuroleptic drug exposure was considered, a trend toward lower kinetic parameters was found in schizophrenics with a history of prior neuroleptic usage. We conclude that platelet MAO activity is, in chronic schizophrenics, both quantitatively reduced and qualitatively different from control enzyme. We suggest that the measurement of Km in addition to the measurement of Vmax may be a useful biological marker for chronic schizophrenia providing that the appropriate substrates are employed.

Original languageEnglish (US)
Pages (from-to)1947-1951
Number of pages5
JournalLife Sciences
Volume28
Issue number17
DOIs
StatePublished - Apr 27 1981
Externally publishedYes

Fingerprint

Phenethylamines
Tyramine
Monoamine Oxidase
Platelets
Antipsychotic Agents
Schizophrenia
Blood Platelets
Kinetics
Substrates
Kinetic parameters
Biomarkers
Enzymes
benzylamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kinetic analysis of platelet monoamine oxidase in chronic schizophrenia. / Breier, Alan; Hitzemann, Robert; Hirschowitz, Jack; Garver, David L.

In: Life Sciences, Vol. 28, No. 17, 27.04.1981, p. 1947-1951.

Research output: Contribution to journalArticle

Breier, Alan ; Hitzemann, Robert ; Hirschowitz, Jack ; Garver, David L. / Kinetic analysis of platelet monoamine oxidase in chronic schizophrenia. In: Life Sciences. 1981 ; Vol. 28, No. 17. pp. 1947-1951.
@article{a489769aa0e5448ea5aacb58cd66bf45,
title = "Kinetic analysis of platelet monoamine oxidase in chronic schizophrenia",
abstract = "Km and Vmax values for platelet monoamine oxidase (MAO) were determined in 16 chronic schizophrenics and 18 controls utilizing three substrates, tyramine (TYR), benzylamine (BZ), and phenylethylamine (PEA). In the chronic schizophrenics decreased Km and Vmax values were found for TYR and BZ but not PEA. When prior neuroleptic drug exposure was considered, a trend toward lower kinetic parameters was found in schizophrenics with a history of prior neuroleptic usage. We conclude that platelet MAO activity is, in chronic schizophrenics, both quantitatively reduced and qualitatively different from control enzyme. We suggest that the measurement of Km in addition to the measurement of Vmax may be a useful biological marker for chronic schizophrenia providing that the appropriate substrates are employed.",
author = "Alan Breier and Robert Hitzemann and Jack Hirschowitz and Garver, {David L.}",
year = "1981",
month = "4",
day = "27",
doi = "10.1016/0024-3205(81)90303-9",
language = "English (US)",
volume = "28",
pages = "1947--1951",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "17",

}

TY - JOUR

T1 - Kinetic analysis of platelet monoamine oxidase in chronic schizophrenia

AU - Breier, Alan

AU - Hitzemann, Robert

AU - Hirschowitz, Jack

AU - Garver, David L.

PY - 1981/4/27

Y1 - 1981/4/27

N2 - Km and Vmax values for platelet monoamine oxidase (MAO) were determined in 16 chronic schizophrenics and 18 controls utilizing three substrates, tyramine (TYR), benzylamine (BZ), and phenylethylamine (PEA). In the chronic schizophrenics decreased Km and Vmax values were found for TYR and BZ but not PEA. When prior neuroleptic drug exposure was considered, a trend toward lower kinetic parameters was found in schizophrenics with a history of prior neuroleptic usage. We conclude that platelet MAO activity is, in chronic schizophrenics, both quantitatively reduced and qualitatively different from control enzyme. We suggest that the measurement of Km in addition to the measurement of Vmax may be a useful biological marker for chronic schizophrenia providing that the appropriate substrates are employed.

AB - Km and Vmax values for platelet monoamine oxidase (MAO) were determined in 16 chronic schizophrenics and 18 controls utilizing three substrates, tyramine (TYR), benzylamine (BZ), and phenylethylamine (PEA). In the chronic schizophrenics decreased Km and Vmax values were found for TYR and BZ but not PEA. When prior neuroleptic drug exposure was considered, a trend toward lower kinetic parameters was found in schizophrenics with a history of prior neuroleptic usage. We conclude that platelet MAO activity is, in chronic schizophrenics, both quantitatively reduced and qualitatively different from control enzyme. We suggest that the measurement of Km in addition to the measurement of Vmax may be a useful biological marker for chronic schizophrenia providing that the appropriate substrates are employed.

UR - http://www.scopus.com/inward/record.url?scp=0019795412&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019795412&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(81)90303-9

DO - 10.1016/0024-3205(81)90303-9

M3 - Article

VL - 28

SP - 1947

EP - 1951

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 17

ER -