TY - JOUR
T1 - Kill
T2 - Boosting HIV-specific immune responses
AU - Trautmann, Lydie
N1 - Funding Information:
This work was supported by the following sources: NIH grant R01AI108433, R21AI116233 and a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the US Department of Defense (DoD). The views expressed are those of the authors and should not be construed to represent the positions of the US Army or the Department of Defense.
Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Purpose of review: Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8+ T cells is a promising way to achieve an HIV cure. Recent findings: Recent studies provided the rationale for developing immune interventions to increase the numbers, function and location of HIV-specific CD8+ T cells to purge HIV reservoirs. Multiple approaches are being evaluated including very early suppression of HIV replication in acute infection, adoptive cell transfer, therapeutic vaccination or use of immunomodulatory molecules. New assays to measure the killing and antiviral function of induced HIV-specific CD8+ T cells have been developed to assess the efficacy of these new approaches. The strategies combining HIV reactivation and immunobased therapies to boost HIV-specific CD8+ T cells can be tested in in-vivo and in-silico models to accelerate the design of new clinical trials. Summary: New immunobased strategies are explored to boost HIV-specific CD8+ T cells able to purge the HIV-infected cells with the ultimate goal of achieving spontaneous control of viral replication without antiretroviral treatment.
AB - Purpose of review: Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8+ T cells is a promising way to achieve an HIV cure. Recent findings: Recent studies provided the rationale for developing immune interventions to increase the numbers, function and location of HIV-specific CD8+ T cells to purge HIV reservoirs. Multiple approaches are being evaluated including very early suppression of HIV replication in acute infection, adoptive cell transfer, therapeutic vaccination or use of immunomodulatory molecules. New assays to measure the killing and antiviral function of induced HIV-specific CD8+ T cells have been developed to assess the efficacy of these new approaches. The strategies combining HIV reactivation and immunobased therapies to boost HIV-specific CD8+ T cells can be tested in in-vivo and in-silico models to accelerate the design of new clinical trials. Summary: New immunobased strategies are explored to boost HIV-specific CD8+ T cells able to purge the HIV-infected cells with the ultimate goal of achieving spontaneous control of viral replication without antiretroviral treatment.
KW - HIV-specific CD8 T cells
KW - immunobased therapies
KW - posttreatment control of HIV replication
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U2 - 10.1097/COH.0000000000000286
DO - 10.1097/COH.0000000000000286
M3 - Review article
C2 - 27054280
AN - SCOPUS:84964056747
VL - 11
SP - 409
EP - 416
JO - Current Opinion in HIV and AIDS
JF - Current Opinion in HIV and AIDS
SN - 1746-630X
IS - 4
ER -