KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes

Khoa D. Tran, Dayana Rodriguez-Contreras, Danielle P. Vieira, Phillip A. Yates, Larry David, Wandy Beatty, Johannes Elferich, Scott M. Landfear

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: The mechanism for selectively targeting membrane proteins to the flagellum of kinetoplastid parasites is unknown. Results: We have identified a novel protein, KHARON1, which is important for the flagellar targeting of a glucose transporter. Conclusion: KHARON1 is the first protein identified in Kinetoplastida that targets a membrane protein to the flagellum. Significance: KHARON1 may be part of a new flagellar targeting pathway.

Original languageEnglish (US)
Pages (from-to)22721-22733
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number31
DOIs
StatePublished - Aug 2 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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