@article{24020df8c72c45aba5da5174cc016416,
title = "Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)",
abstract = "Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan. The latter includes two distinct ALS/PDC-affected regions (Hohara and Kozagawa), where the disorder is known as Muro disease. In Hohara, oral exposure to plant (cycad) neurotoxins used in traditional medical practice has been linked previously to Muro disease. We report new observations that link Kampō medicine to Muro disease in the southern Kozagawa focus. Oral exposure to cycad seed toxins is associated with all three foci of Western Pacific ALS/PDC.",
keywords = "Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex, Cycad seed, Honshu, Japan, Kii peninsula, Sotetsu, Traditional/folk medical practice",
author = "Spencer, {Peter S.} and Palmer, {Valerie S.} and Tameko Kihira and Sohei Yoshida and Jacques Reis and Momoko Yabushita and Yoshiro Yase",
note = "Funding Information: We thank the Kozagawa Department of Education for assistance in arranging interviews with Mitogawa residents. Research conducted in 1986-1987 [3] was funded by U.S. National Institute of Environmental Health Sciences grant ES11384 and NIH Fogarty Framework Program for Global Health grant TW008097 , with assistance from the Third World Medical Research Foundation. Funding Information: We thank the Kozagawa Department of Education for assistance in arranging interviews with Mitogawa residents. Research conducted in 1986-1987 [3] was funded by U.S. National Institute of Environmental Health Sciences grant ES11384 and NIH Fogarty Framework Program for Global Health grant TW008097, with assistance from the Third World Medical Research Foundation. Publisher Copyright: {\textcopyright} 2020",
year = "2020",
month = mar,
doi = "10.1016/j.ensci.2020.100230",
language = "English (US)",
volume = "18",
journal = "eNeurologicalSci",
issn = "2405-6502",
publisher = "Elsevier BV",
}