Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a nonhuman primate

Michael Axthelm, Dennis Bourdette, Gail Marracci, Weiping Su, Elizabeth T. Mullaney, Minsha Manoharan, Steven Kohama, Jim Pollaro, Ellen Witkowski, Paul Wang, William Rooney, Lawrence (Larry) Sherman, Scott Wong

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: To describe Japanese macaque encephalomyelitis (JME), a spontaneous inflammatory demyelinating disease occurring in the Oregon National Primate Research Center's (ONPRC) colony of Japanese macaques (JMs, Macaca fuscata). Methods: JMs with neurologic impairment were removed from the colony, evaluated, and treated with supportive care. Animals were humanely euthanized and their central nervous systems (CNSs) were examined. Results: ONPRC's JM colony was established in 1965 and no cases of JME occurred until 1986. Since 1986, 57 JMs spontaneously developed a disease characterized clinically by paresis of 1 or more limbs, ataxia, or ocular motor paresis. Most animals were humanely euthanized during their initial episode. Three recovered, later relapsed, and were then euthanized. There was no gender predilection and the median age for disease was 4 years. Magnetic resonance imaging of 8 cases of JME revealed multiple gadolinium-enhancing T1-weighted hyperintensities in the white matter of the cerebral hemispheres, brainstem, cerebellum, and cervical spinal cord. The CNS of monkeys with JME contained multifocal plaque-like demyelinated lesions of varying ages, including acute and chronic, active demyelinating lesions with macrophages and lymphocytic periventricular infiltrates, and chronic, inactive demyelinated lesions. A previously undescribed gamma-herpesvirus was cultured from acute JME white matter lesions. Cases of JME continue to affect 1% to 3% of the ONPRC colony per year. Interpretation: JME is a unique spontaneous disease in a nonhuman primate that has similarities with multiple sclerosis (MS) and is associated with a novel simian herpesvirus. Elucidating the pathogenesis of JME may shed new light on MS and other human demyelinating diseases.

Original languageEnglish (US)
Pages (from-to)362-373
Number of pages12
JournalAnnals of Neurology
Volume70
Issue number3
DOIs
StatePublished - Sep 2011

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Encephalomyelitis
Macaca
Primates
Multiple Sclerosis
Demyelinating Diseases
Paresis
Central Nervous System
Cercopithecine Herpesvirus 1
Herpesviridae
Gadolinium
Cerebrum
Ataxia
Research
Cerebellum
Nervous System
Brain Stem
Macrophages
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Japanese macaque encephalomyelitis : A spontaneous multiple sclerosis-like disease in a nonhuman primate. / Axthelm, Michael; Bourdette, Dennis; Marracci, Gail; Su, Weiping; Mullaney, Elizabeth T.; Manoharan, Minsha; Kohama, Steven; Pollaro, Jim; Witkowski, Ellen; Wang, Paul; Rooney, William; Sherman, Lawrence (Larry); Wong, Scott.

In: Annals of Neurology, Vol. 70, No. 3, 09.2011, p. 362-373.

Research output: Contribution to journalArticle

Axthelm, Michael ; Bourdette, Dennis ; Marracci, Gail ; Su, Weiping ; Mullaney, Elizabeth T. ; Manoharan, Minsha ; Kohama, Steven ; Pollaro, Jim ; Witkowski, Ellen ; Wang, Paul ; Rooney, William ; Sherman, Lawrence (Larry) ; Wong, Scott. / Japanese macaque encephalomyelitis : A spontaneous multiple sclerosis-like disease in a nonhuman primate. In: Annals of Neurology. 2011 ; Vol. 70, No. 3. pp. 362-373.
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AU - Mullaney, Elizabeth T.

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AU - Kohama, Steven

AU - Pollaro, Jim

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