Isoflurane actions on central nervous system and cardiovascular toxicity of bupivacaine in rats

K. S K Ghana, D. Morrow, Michael Andresen

Research output: Contribution to journalArticle

Abstract

Regional anesthesia is frequently used to supplement light general anesthesia (GA). Central nervous system (CNS) and cardiovascular (CV) toxicity of local anesthetics (LA) such as bupivacaine (BUP) are well described including CV collapse. Effects of GA on LA toxicity are not well defined. To examine the possible interactions between GA-LA, we studied the responses to intravenous (iv) BUP in conscious (CON) rats (n=9) and in rats anesthetized with isoflurane (ISO, via endotracheal tube, n=5). In CON rats, BUP, 2mg/kg, caused hypertension, bradycardia, dysmythmias and tonic-clonic seizures (75%); all following early (within a few sec), transient, complex EKG wave form changes. Compared to CON, ISO (1%) eliminated BUPinduced seizures and dysrhythmias and reduced but did not eliminate CV response to BUP or EKG changes. ISO attenuated baroreflex (BRX) gain, but ISO + BUP eliminated BRX. Our results suggest that ISO prevents early signs of CMS (seizures) and CV (MAP, dysrhythmias) toxicity of BUP. > This may exacerbate impending CV collapse and BRX depression may ' facilitate the crisis induced by BUP.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

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Isoflurane
isoflurane
Bupivacaine
Neurology
local anesthetics
central nervous system
Toxicity
Rats
anesthesia
seizures
Central Nervous System
toxicity
rats
Baroreflex
Local Anesthetics
General Anesthesia
Seizures
Electrocardiography
hypertension
Conduction Anesthesia

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Isoflurane actions on central nervous system and cardiovascular toxicity of bupivacaine in rats. / Ghana, K. S K; Morrow, D.; Andresen, Michael.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

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