Abstract
The present study investigates the possible relationship between human β-cell secretory capacity and polymorphism in the 5'-flanking region of the human insulin gene. The glucose potentiation slope was measured in normal and non-insulin-dependent diabetic subjects (NIDDM). This slope, as reported previously, is an index of the ability of hyperglycemia to potentiate the insulin response the arginine and as such is a measure of β-cell responsiveness to glucose. Restriction enzyme analysis using a human insulin gene probe was performed on leukocyte DNA isolated from the same individuals. We conclude that a 1.6 kb polymorphism in the 5'-flanking region of the human insulin gene in both normal and NIDDM subjects has no association with insulin secretory responss as defined here by the glucose potentiation slope.
Original language | English (US) |
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Pages (from-to) | 311-314 |
Number of pages | 4 |
Journal | Diabetes |
Volume | 34 |
Issue number | 4 |
DOIs | |
State | Published - 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism