Islet β-cell function and polymorphism in the 5'-flanking region of the human insulin gene

M. A. Permutt, P. Rotwein, T. Andreone, W. K. Ward, D. Porte

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The present study investigates the possible relationship between human β-cell secretory capacity and polymorphism in the 5'-flanking region of the human insulin gene. The glucose potentiation slope was measured in normal and non-insulin-dependent diabetic subjects (NIDDM). This slope, as reported previously, is an index of the ability of hyperglycemia to potentiate the insulin response the arginine and as such is a measure of β-cell responsiveness to glucose. Restriction enzyme analysis using a human insulin gene probe was performed on leukocyte DNA isolated from the same individuals. We conclude that a 1.6 kb polymorphism in the 5'-flanking region of the human insulin gene in both normal and NIDDM subjects has no association with insulin secretory responss as defined here by the glucose potentiation slope.

Original languageEnglish (US)
Pages (from-to)311-314
Number of pages4
JournalDiabetes
Volume34
Issue number4
StatePublished - 1985
Externally publishedYes

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5' Flanking Region
Islets of Langerhans
Insulin
Genes
Glucose
Type 2 Diabetes Mellitus
Restriction Mapping
Hyperglycemia
Arginine
Leukocytes
DNA

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Permutt, M. A., Rotwein, P., Andreone, T., Ward, W. K., & Porte, D. (1985). Islet β-cell function and polymorphism in the 5'-flanking region of the human insulin gene. Diabetes, 34(4), 311-314.

Islet β-cell function and polymorphism in the 5'-flanking region of the human insulin gene. / Permutt, M. A.; Rotwein, P.; Andreone, T.; Ward, W. K.; Porte, D.

In: Diabetes, Vol. 34, No. 4, 1985, p. 311-314.

Research output: Contribution to journalArticle

Permutt, MA, Rotwein, P, Andreone, T, Ward, WK & Porte, D 1985, 'Islet β-cell function and polymorphism in the 5'-flanking region of the human insulin gene', Diabetes, vol. 34, no. 4, pp. 311-314.
Permutt MA, Rotwein P, Andreone T, Ward WK, Porte D. Islet β-cell function and polymorphism in the 5'-flanking region of the human insulin gene. Diabetes. 1985;34(4):311-314.
Permutt, M. A. ; Rotwein, P. ; Andreone, T. ; Ward, W. K. ; Porte, D. / Islet β-cell function and polymorphism in the 5'-flanking region of the human insulin gene. In: Diabetes. 1985 ; Vol. 34, No. 4. pp. 311-314.
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