Iron in mammals: Pathophysiological mechanisms of overload and deficiency in relation to disease

Martha B. Johnson, Caroline Enns, An-Sheng Zhang

Research output: Contribution to journalArticle

Abstract

The uptake of iron into the body is tightly regulated in humans and in other mammals. Mutations in key proteins that transport, sense, metabolize, and facilitate the utilization of iron cause perturbations in iron homeostasis that result in iron deficiency or overload diseases. This review focuses on what is currently known about these diseases and the normal function of the proteins that are mutated in the disease-state. The proteins causing hereditary hemochromatosis and anemia are discussed in detail.

Original languageEnglish (US)
Pages (from-to)155-191
Number of pages37
JournalTopics in Current Genetics
Volume14
DOIs
StatePublished - 2006

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Mammals
Iron
Hemochromatosis
Protein Transport
Anemia
Proteins
Homeostasis
Mutation

ASJC Scopus subject areas

  • Genetics
  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Iron in mammals : Pathophysiological mechanisms of overload and deficiency in relation to disease. / Johnson, Martha B.; Enns, Caroline; Zhang, An-Sheng.

In: Topics in Current Genetics, Vol. 14, 2006, p. 155-191.

Research output: Contribution to journalArticle

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