Invited Commentary: The Causal Association between Obesity and Stillbirth-Strengths and Limitations of the Consecutive-Pregnancies Approach

Jonathan Snowden, Stephanie A. Leonard

Research output: Contribution to journalReview article

Abstract

There has been a resurgence in analyses of consecutive pregnancies (or similarly, sibling designs) in perinatal and pediatric epidemiology. These approaches have attractive qualities for estimating associations with complex multifactorial exposures like obesity. In an article appearing in this issue of the Journal, Yu et al. (Am J Epidemiol. 2019;188(7):1328-1336) apply a consecutive-pregnancies approach to characterize the risk of stillbirth among women who develop obesity between pregnancies ("incident obesity"). Working within a causal framework and using parametric and nonparametric estimation techniques, the authors find an increase in stillbirth risk associated with incident obesity. Risk differences varied between 0.4 per 1,000 births (95% confidence interval (CI): 0.1, 0.7) and 6.9 per 1,000 births (95% CI: 3.7, 10.0), and risk ratios ranged from 1.12 (95% CI: 1.02, 1.23) to 2.99 (95% CI: 2.19, 4.08). The strengths of this approach include starting from a clearly defined causal estimand and exploring the sensitivity of parameter estimates to model selection. In this commentary, we put these findings in the broader context of research on obesity and birth outcomes and highlight concerns regarding the generalizability of results derived from within-family designs. We conclude that while causal inference is an important goal, in some instances focusing on formulation of a causal question drives results away from broad applicability.

Original languageEnglish (US)
Article numberkwz079
Pages (from-to)1337-1342
Number of pages6
JournalAmerican journal of epidemiology
Volume188
Issue number7
DOIs
StatePublished - Jan 1 2019

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Stillbirth
Obesity
Pregnancy
Confidence Intervals
Parturition
Siblings
Epidemiology
Odds Ratio
Pediatrics
Research

Keywords

  • birth outcomes
  • causal inference
  • generalizability
  • obesity
  • pregnancy
  • stillbirth

ASJC Scopus subject areas

  • Epidemiology

Cite this

Invited Commentary : The Causal Association between Obesity and Stillbirth-Strengths and Limitations of the Consecutive-Pregnancies Approach. / Snowden, Jonathan; Leonard, Stephanie A.

In: American journal of epidemiology, Vol. 188, No. 7, kwz079, 01.01.2019, p. 1337-1342.

Research output: Contribution to journalReview article

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