Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture

A. Raman, Z. X. Lin, E. Sviderskaya, D. Kowalska

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalJournal of Ethnopharmacology
Volume54
Issue number2-3
DOIs
StatePublished - Nov 1 1996

Keywords

  • Angelica sinensis root
  • Mouse melan-a cell line
  • Proliferation
  • TCM
  • Vitiligo

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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