Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture

A. Raman; Z. X. Lin; E. Sviderskaya; D. Kowalska

doi:10.1016/S0378-8741(96)01458-4

Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture

A. Raman, Z. X. Lin, E. Sviderskaya, D. Kowalska

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.

Original language	English (US)
Pages (from-to)	165-170
Number of pages	6
Journal	Journal of Ethnopharmacology
Volume	54
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-8741(96)01458-4
State	Published - Nov 1996
Externally published	Yes

Keywords

Angelica sinensis root
Mouse melan-a cell line
Proliferation
TCM
Vitiligo

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/S0378-8741(96)01458-4

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title = "Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture",

abstract = "Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.",

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AU - Raman, A.

AU - Lin, Z. X.

AU - Sviderskaya, E.

AU - Kowalska, D.

PY - 1996/11

Y1 - 1996/11

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AB - Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.

KW - Angelica sinensis root

KW - Mouse melan-a cell line

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KW - TCM

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Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture

Abstract

Keywords

ASJC Scopus subject areas

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