Abstract
Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 165-170 |
| Number of pages | 6 |
| Journal | Journal of Ethnopharmacology |
| Volume | 54 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Nov 1996 |
| Externally published | Yes |
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Keywords
- Angelica sinensis root
- Mouse melan-a cell line
- Proliferation
- TCM
- Vitiligo
ASJC Scopus subject areas
- Pharmacology
Cite this
Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture. / Soumyanath, Amala; Lin, Z. X.; Sviderskaya, E.; Kowalska, D.
In: Journal of Ethnopharmacology, Vol. 54, No. 2-3, 11.1996, p. 165-170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture
AU - Soumyanath, Amala
AU - Lin, Z. X.
AU - Sviderskaya, E.
AU - Kowalska, D.
PY - 1996/11
Y1 - 1996/11
N2 - Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.
AB - Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.
KW - Angelica sinensis root
KW - Mouse melan-a cell line
KW - Proliferation
KW - TCM
KW - Vitiligo
UR - http://www.scopus.com/inward/record.url?scp=0030296615&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030296615&partnerID=8YFLogxK
U2 - 10.1016/S0378-8741(96)01458-4
DO - 10.1016/S0378-8741(96)01458-4
M3 - Article
VL - 54
SP - 165
EP - 170
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 2-3
ER -