Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture

Amala Soumyanath, Z. X. Lin, E. Sviderskaya, D. Kowalska

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalJournal of Ethnopharmacology
Volume54
Issue number2-3
DOIs
StatePublished - Nov 1996
Externally publishedYes

Fingerprint

Angelica sinensis
Melanocytes
Vitiligo
Chinese Traditional Medicine
Thin Layer Chromatography
Cell Division
Therapeutics

Keywords

  • Angelica sinensis root
  • Mouse melan-a cell line
  • Proliferation
  • TCM
  • Vitiligo

ASJC Scopus subject areas

  • Pharmacology

Cite this

Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture. / Soumyanath, Amala; Lin, Z. X.; Sviderskaya, E.; Kowalska, D.

In: Journal of Ethnopharmacology, Vol. 54, No. 2-3, 11.1996, p. 165-170.

Research output: Contribution to journalArticle

@article{7ae1994df74a4ae8bc71f5e318388ee7,
title = "Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture",
abstract = "Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.",
keywords = "Angelica sinensis root, Mouse melan-a cell line, Proliferation, TCM, Vitiligo",
author = "Amala Soumyanath and Lin, {Z. X.} and E. Sviderskaya and D. Kowalska",
year = "1996",
month = "11",
doi = "10.1016/S0378-8741(96)01458-4",
language = "English (US)",
volume = "54",
pages = "165--170",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "2-3",

}

TY - JOUR

T1 - Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture

AU - Soumyanath, Amala

AU - Lin, Z. X.

AU - Sviderskaya, E.

AU - Kowalska, D.

PY - 1996/11

Y1 - 1996/11

N2 - Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.

AB - Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 μg/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolyprrolidone, which was shown by thin layer chromatography to reduce the coumarin content.

KW - Angelica sinensis root

KW - Mouse melan-a cell line

KW - Proliferation

KW - TCM

KW - Vitiligo

UR - http://www.scopus.com/inward/record.url?scp=0030296615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030296615&partnerID=8YFLogxK

U2 - 10.1016/S0378-8741(96)01458-4

DO - 10.1016/S0378-8741(96)01458-4

M3 - Article

VL - 54

SP - 165

EP - 170

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 2-3

ER -