Intravoxel incoherent motion imaging kinetics during chemoradiotherapy for human papillomavirus-associated squamous cell carcinoma of the oropharynx

Preliminary results from a prospective pilot study

Yao Ding, John D. Hazle, Abdallah S R Mohamed, Steven J. Frank, Brian P. Hobbs, Rivka R. Colen, G. Brandon Gunn, Jihong Wang, Jayashree Kalpathy-Cramer, Adam S. Garden, Stephen Y. Lai, David I. Rosenthal, Clifton D. Fuller

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This study aims to identify the temporal kinetics of intravoxel incoherent motion (IVIM) MRI in patients with human papillomavirus-associated (HPV+) oropharyngeal squamous cell carcinoma. Patients were enrolled under an Institutional Review Board (IRB)-approved protocol as part of an ongoing prospective clinical trial. All patients underwent two MRI studies: a baseline scan before chemoradiotherapy and a mid-treatment scan 3-4 weeks after treatment initiation. Parametric maps representing pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) were generated. The Mann-Whitney U-test was used to assess the temporal variation of IVIM metrics. Bayesian quadratic discriminant analysis (QDA) was used to evaluate the extent to which mid-treatment changes in IVIM metrics could be combined to predict sites that would achieve complete response (CR) in multivariate analysis. Thirty-one patients were included in the final analysis with 59 lesions. Pretreatment ADC and D values of the CR lesions (n=19) were significantly lower than those of non-CR lesions (n=33). Mid-treatment ADC, D and f values were significantly higher (p

Original languageEnglish (US)
Pages (from-to)1645-1654
Number of pages10
JournalNMR in Biomedicine
Volume28
Issue number12
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Fingerprint

Chemoradiotherapy
Oropharynx
Squamous Cell Carcinoma
Prospective Studies
Imaging techniques
Kinetics
Magnetic resonance imaging
Research Ethics Committees
Discriminant Analysis
Discriminant analysis
Therapeutics
Nonparametric Statistics
Multivariate Analysis
Perfusion
Epithelial Cells
Clinical Trials

Keywords

  • Chemoradiotherapy
  • HPV-associated oropharyngeal cancer
  • Intravoxel incoherent motion imaging
  • Response assessment

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Intravoxel incoherent motion imaging kinetics during chemoradiotherapy for human papillomavirus-associated squamous cell carcinoma of the oropharynx : Preliminary results from a prospective pilot study. / Ding, Yao; Hazle, John D.; Mohamed, Abdallah S R; Frank, Steven J.; Hobbs, Brian P.; Colen, Rivka R.; Gunn, G. Brandon; Wang, Jihong; Kalpathy-Cramer, Jayashree; Garden, Adam S.; Lai, Stephen Y.; Rosenthal, David I.; Fuller, Clifton D.

In: NMR in Biomedicine, Vol. 28, No. 12, 01.12.2015, p. 1645-1654.

Research output: Contribution to journalArticle

Ding, Y, Hazle, JD, Mohamed, ASR, Frank, SJ, Hobbs, BP, Colen, RR, Gunn, GB, Wang, J, Kalpathy-Cramer, J, Garden, AS, Lai, SY, Rosenthal, DI & Fuller, CD 2015, 'Intravoxel incoherent motion imaging kinetics during chemoradiotherapy for human papillomavirus-associated squamous cell carcinoma of the oropharynx: Preliminary results from a prospective pilot study', NMR in Biomedicine, vol. 28, no. 12, pp. 1645-1654. https://doi.org/10.1002/nbm.3412
Ding, Yao ; Hazle, John D. ; Mohamed, Abdallah S R ; Frank, Steven J. ; Hobbs, Brian P. ; Colen, Rivka R. ; Gunn, G. Brandon ; Wang, Jihong ; Kalpathy-Cramer, Jayashree ; Garden, Adam S. ; Lai, Stephen Y. ; Rosenthal, David I. ; Fuller, Clifton D. / Intravoxel incoherent motion imaging kinetics during chemoradiotherapy for human papillomavirus-associated squamous cell carcinoma of the oropharynx : Preliminary results from a prospective pilot study. In: NMR in Biomedicine. 2015 ; Vol. 28, No. 12. pp. 1645-1654.
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