Intrauterine insemination-ready versus conventional semen cryopreservation for donor insemination: A comparison of retrospective results and a prospective, randomized trial

Don P. Wolf, Phillip E. Patton, Kenneth A. Burry, Paul F. Kaplan

Research output: Contribution to journalArticle

12 Scopus citations


Objective: To compare fecundity rates following intrauterine insemination (IUI) with donor sperm frozen conventionally versus an IUI-ready preparation. Design: Both retrospective results and a prospective, randomized study where recipients were assigned to one of two sperm cryopreservation methods in each cycle of intrauterine insemination are reported. Setting: University-based infertility practice, affiliated private practices, and andrology laboratory. Patient(s): Women desiring therapeutic insemination in an effort to establish pregnancy. Intervention(s): Intrauterine insemination with donor sperm frozen conventionally or by an IUI-ready protocol. Main Outcome Measure(s): Cycle fecundity in donor IUI recipients. Result(s): In a retrospective analysis involving 642 inseminations in 209 recipients, 79 pregnancies were recorded for an overall pregnancy rate of 12.3% per insemination (or cycle): 11.3% with IUI-ready sperm and 13.9% with conventionally preserved sperm. In a follow-up prospective, randomized study, the pregnancy rate for IUI-ready sperm preparations was 36% per cycle (14 of 39) whereas that for conventionally preserved sperm was 19.6% per cycle (9 of 46). Thirteen of the 23 pregnancies occurred in the first study cycle of insemination; only two pregnancies were observed in patients undergoing more than four cycles of insemination. Conclusion(s): Cycle fecundity for IUI-ready donor sperm is equivalent to conventional cryopreserved sperm based on both prospective and retrospective assessments.

Original languageEnglish (US)
Pages (from-to)181-185
Number of pages5
JournalFertility and sterility
Issue number1
StatePublished - Jul 12 2001



  • Donor insemination
  • IUI-ready
  • intrauterine insemination
  • prospective clinical trial
  • sperm cryopreservation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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