Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques

Hajime Suzuki, Makiko Motohara, Ariko Miyake, Kentaro Ibuki, Yoshinori Fukazawa, Katsuhisa Inaba, Kyoko Masuda, Nagahiro Minato, Hiroshi Kawamoto, Masanori Hayami, Tomoyuki Miura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We intrarectally infected newborn macaques with a pathogenic simian/human immunodeficiency virus (SHIV) that induced rapid and profound CD4+ T cell depletion, and examined the early effects of this SHIV on the thymus. After intrarectal infection, viral loads were much higher in the thymus than in other lymphoid tissues in newborns. In contrast, no clear difference was seen in the viral loads of different tissues in adults. Histological and immunohistochemical observations showed severe thymic involution. Depletion of CD4+ thymocytes began in the medulla at 2 weeks post infection and spread over the whole thymus. After in vivo infection, the CD2+ subpopulation, which represents a relatively later stage of T cell progenitors, was selectively reduced and development of thymocytes from CD3-CD4 -CD8- cells to CD4+CD8+ cells was impaired. These results suggest that profound and irreversible loss of CD4 + cells that are observed in the peripheral blood of SHIV-infected monkeys are due to destruction of the thymus and impaired thymopoiesis as a result of SHIV infection in the thymus.

Original languageEnglish (US)
Pages (from-to)667-679
Number of pages13
JournalMicrobiology and Immunology
Volume49
Issue number7
StatePublished - 2005
Externally publishedYes

Fingerprint

Simian Immunodeficiency Virus
Macaca
Virus Diseases
Thymus Gland
HIV
Thymocytes
Viral Load
Infection
T-Lymphocytes
Lymphoid Tissue
Haplorhini

Keywords

  • Newborn
  • Rhesus monkey
  • SHIV
  • Thymopoiesis

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Microbiology

Cite this

Suzuki, H., Motohara, M., Miyake, A., Ibuki, K., Fukazawa, Y., Inaba, K., ... Miura, T. (2005). Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques. Microbiology and Immunology, 49(7), 667-679.

Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques. / Suzuki, Hajime; Motohara, Makiko; Miyake, Ariko; Ibuki, Kentaro; Fukazawa, Yoshinori; Inaba, Katsuhisa; Masuda, Kyoko; Minato, Nagahiro; Kawamoto, Hiroshi; Hayami, Masanori; Miura, Tomoyuki.

In: Microbiology and Immunology, Vol. 49, No. 7, 2005, p. 667-679.

Research output: Contribution to journalArticle

Suzuki, H, Motohara, M, Miyake, A, Ibuki, K, Fukazawa, Y, Inaba, K, Masuda, K, Minato, N, Kawamoto, H, Hayami, M & Miura, T 2005, 'Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques', Microbiology and Immunology, vol. 49, no. 7, pp. 667-679.
Suzuki H, Motohara M, Miyake A, Ibuki K, Fukazawa Y, Inaba K et al. Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques. Microbiology and Immunology. 2005;49(7):667-679.
Suzuki, Hajime ; Motohara, Makiko ; Miyake, Ariko ; Ibuki, Kentaro ; Fukazawa, Yoshinori ; Inaba, Katsuhisa ; Masuda, Kyoko ; Minato, Nagahiro ; Kawamoto, Hiroshi ; Hayami, Masanori ; Miura, Tomoyuki. / Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques. In: Microbiology and Immunology. 2005 ; Vol. 49, No. 7. pp. 667-679.
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