Intrapericardial minocycline sclerosis for malignant pericardial effusion

Ilan Lashevsky, Rami Ben Yosef, Diana Rinkevich, Shimon Reisner, Walter Markiewicz

    Research output: Contribution to journalArticle

    24 Scopus citations

    Abstract

    Study objective: To evaluate the effectiveness and safety of minocycline hydrochloride (minocycline) intrapericardially in patients with malignant pericardial effusion. Design: Consecutive patients admitted to the hospital during a 32-month period received intrapericardial minocycline. Setting: A 900-bed university hospital. Patients: Fourteen consecutive patients with malignant pcricardial effusion. Intervention: Following percutaneous insertion of a pericardial drain, minocycline was administered at a dosage of 10 mg/kg every 48 h until fluid drainage stopped or until further therapy was deemed necessary. Measurements: Complications associated with therapy, total minocycline requirements, immediate and late failure of therapy, and clinical and echocardiographic follow-up of at least 6 months. Results: Mean amount of minocycline administered was 1.9±1.0 g given in 2.4 divided doses. Total drainage time was 5.4±2.5 days. Recurrence of malignant pericardial effusion was seen in only 1 of 14 patients. Death occurred in 10 patients due to severe metastatic disease in all. Minocycline instillation was associated with severe chest pain in seven patients, and with ECG changes suggesting pericardial or subepicardial injury in two patients. Conclusion: (1) Intrapericardial minocycline instillation is very effective in preventing rccurrence of malignant pericardial effusion. (2) Minocycline is irritative to the pericardium and may cause severe chest pain with transient ECG changes, suggesting pericardial or subepicardial injury.

    Original languageEnglish (US)
    Pages (from-to)1452-1454
    Number of pages3
    JournalCHEST
    Volume109
    Issue number6
    DOIs
    StatePublished - Jan 1 1996

    Keywords

    • cardiac tamponade
    • minocycline
    • pericardial effusion
    • tetracycline

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Critical Care and Intensive Care Medicine
    • Cardiology and Cardiovascular Medicine

    Fingerprint Dive into the research topics of 'Intrapericardial minocycline sclerosis for malignant pericardial effusion'. Together they form a unique fingerprint.

  • Cite this

    Lashevsky, I., Yosef, R. B., Rinkevich, D., Reisner, S., & Markiewicz, W. (1996). Intrapericardial minocycline sclerosis for malignant pericardial effusion. CHEST, 109(6), 1452-1454. https://doi.org/10.1378/chest.109.6.1452