Intracellular transport and processing of secretory component in cultured rat hepatocytes

Linda Musil, Jacques U. Baenziger

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Membrane secretory component (mSC) mediates the transcellular transport of polymeric immunoglobulin A from the sinusoidal surface of rat hepatocytes to the bile, where it is released as a proteolytic fragment, fSC. We have examined the biosynthesis, posttranslational processing, transport, and cleavage of secretory component in cultured rat hepatocytes. Membrane secretory component is detected at the cell surface beginning 1.0-1.5 h after synthesis, whereas fSC is not found in the medium until 2.5-3 h after synthesis. Approximately 16% of metabolically labeled mSC is accessible at the cell surface at 4 °C. Surface accessible mSC labeled with 125I at 4 °C is internalized with a half-time of

Original languageEnglish (US)
Pages (from-to)1194-1204
Number of pages11
JournalGastroenterology
Volume93
Issue number6
StatePublished - 1987
Externally publishedYes

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Secretory Component
Hepatocytes
Membranes
Transcytosis
Bile
Immunoglobulin A

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Intracellular transport and processing of secretory component in cultured rat hepatocytes. / Musil, Linda; Baenziger, Jacques U.

In: Gastroenterology, Vol. 93, No. 6, 1987, p. 1194-1204.

Research output: Contribution to journalArticle

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