Intracellular recordings from cochlear inner hair cells: Effects of stimulation of the crossed olivocochlear efferents

M. Christian Brown, Alfred Nuttall, Robert I. Masta

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Intracellular recordings were obtained from inner hair cells located in the lower basal turn of the guinea pig cochlea. At low sound pressure levels the inner hair cells were highly frequency selective, producing receptor potentials only in response to sound frequencies between about 16 and 24 kilohertz. Electrical stimulation of efferent nerves in the crossed olivocochlear bundle markedly reduced these receptor potentials while causing little change in the resting membrane potential. At high sound levels, where cells responded to an increasingly wider range of sound frequencies, stimulation was less effective in reducing receptor potentials. Since the crossed olivocochlear bundle primarily innervates outer hair cells, these results support an outer hair cell contribution to the most sensitive response region of inner hair cells.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalScience
Volume222
Issue number4619
StatePublished - 1983
Externally publishedYes

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Inner Auditory Hair Cells
Outer Auditory Hair Cells
Cochlea
Membrane Potentials
Electric Stimulation
Guinea Pigs
Pressure

ASJC Scopus subject areas

  • General

Cite this

Intracellular recordings from cochlear inner hair cells : Effects of stimulation of the crossed olivocochlear efferents. / Brown, M. Christian; Nuttall, Alfred; Masta, Robert I.

In: Science, Vol. 222, No. 4619, 1983, p. 69-72.

Research output: Contribution to journalArticle

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