Intestinal growth-promoting properties of glucagon-like peptide-2 in mice

Anne Tsai, Mary Hill, Sylvia L. Asa, Patricia L. Brubaker, Daniel J. Drucker

Research output: Contribution to journalArticle

248 Citations (Scopus)

Abstract

Glucagon-like peptide-2 (GLP-2) has been shown to promote intestinal epithelial proliferation. We studied crypt cell proliferation, enterocyte cell death, and feeding behavior in GLP-2-treated mice GLP-2 had no effect on food consumption [7.7 ± 0.3 vs. 8.0 ± 0.4 g/day, saline (control) vs. GLP- 2-treated mice, P = not significant]; however, GLP-2 increased the crypt cell proliferation rate (46.0 ± 1 vs. 57 ± 5%, control vs. GLP-2, P <0.01) and decreased the enterocyte apoptotic rate (5.9 ± 0.7 vs. 2.8 ± 0.2% apoptotic cells, control vs. GLP-2, P <0.05) in small bowel (SB) epithelium. GLP-2 induced a significant increase in SB weight (1.3- to 1.75-fold increase over control, P <0.05 to P <0.001) in mice 1-24 mo of age. Increased SB weight was maintained after daily administration of GLP-2 to mice for 12 wk, and cessation of GLP-2 administration in older mice led to regression of (increased) SB weight and mucosal height. These observations suggest that GLP-2 regulates both cell proliferation and apoptosis and promotes intestinal growth after both short- and long-term administration in vivo.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume273
Issue number1 36-1
StatePublished - Jul 1997
Externally publishedYes

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Glucagon-Like Peptide 2
Growth
Cell proliferation
Enterocytes
Cell Proliferation
Weights and Measures
Feeding Behavior
Cell death
Cell Death

Keywords

  • Apoptosis
  • Bowel
  • Feeding
  • Growth factor

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry
  • Physiology (medical)

Cite this

Tsai, A., Hill, M., Asa, S. L., Brubaker, P. L., & Drucker, D. J. (1997). Intestinal growth-promoting properties of glucagon-like peptide-2 in mice. American Journal of Physiology - Endocrinology and Metabolism, 273(1 36-1).

Intestinal growth-promoting properties of glucagon-like peptide-2 in mice. / Tsai, Anne; Hill, Mary; Asa, Sylvia L.; Brubaker, Patricia L.; Drucker, Daniel J.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 273, No. 1 36-1, 07.1997.

Research output: Contribution to journalArticle

Tsai, Anne ; Hill, Mary ; Asa, Sylvia L. ; Brubaker, Patricia L. ; Drucker, Daniel J. / Intestinal growth-promoting properties of glucagon-like peptide-2 in mice. In: American Journal of Physiology - Endocrinology and Metabolism. 1997 ; Vol. 273, No. 1 36-1.
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