Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system

Seunggu (Jude) Han, Krystof Bankiewicz, Nicholas A. Butowski, Paul S. Larson, Manish K. Aghi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Local delivery of therapeutic agents into the brain has many advantages; however, the inability to predict, visualize and confirm the infusion into the intended target has been a major hurdle in its clinical development. Here, we describe the current workflow and application of the interventional MRI (iMRI) system for catheter placement and real time visualization of infusion. We have applied real time convection-enhanced delivery (CED) of therapeutic agents with iMRI across a number of different clinical trials settings in neuro-oncology and movement disorders. Ongoing developments and accumulating experience with the technique and technology of drug formulations, CED platforms, and iMRI systems will continue to make local therapeutic delivery into the brain more accurate, efficient, effective and safer.

Original languageEnglish (US)
Pages (from-to)635-639
Number of pages5
JournalExpert Review of Neurotherapeutics
Volume16
Issue number6
DOIs
StatePublished - Jun 2 2016
Externally publishedYes

Fingerprint

Interventional Magnetic Resonance Imaging
Convection
Catheters
Central Nervous System
Pharmaceutical Preparations
Drug Compounding
Workflow
Movement Disorders
Brain
Therapeutics
Clinical Trials
Technology

Keywords

  • catheter placement
  • convection enhanced delivery
  • drug delivery
  • Interventional MRI
  • real time

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system. / Han, Seunggu (Jude); Bankiewicz, Krystof; Butowski, Nicholas A.; Larson, Paul S.; Aghi, Manish K.

In: Expert Review of Neurotherapeutics, Vol. 16, No. 6, 02.06.2016, p. 635-639.

Research output: Contribution to journalArticle

Han, Seunggu (Jude) ; Bankiewicz, Krystof ; Butowski, Nicholas A. ; Larson, Paul S. ; Aghi, Manish K. / Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system. In: Expert Review of Neurotherapeutics. 2016 ; Vol. 16, No. 6. pp. 635-639.
@article{870b7d7a09674838a13849ed4a97f1eb,
title = "Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system",
abstract = "Local delivery of therapeutic agents into the brain has many advantages; however, the inability to predict, visualize and confirm the infusion into the intended target has been a major hurdle in its clinical development. Here, we describe the current workflow and application of the interventional MRI (iMRI) system for catheter placement and real time visualization of infusion. We have applied real time convection-enhanced delivery (CED) of therapeutic agents with iMRI across a number of different clinical trials settings in neuro-oncology and movement disorders. Ongoing developments and accumulating experience with the technique and technology of drug formulations, CED platforms, and iMRI systems will continue to make local therapeutic delivery into the brain more accurate, efficient, effective and safer.",
keywords = "catheter placement, convection enhanced delivery, drug delivery, Interventional MRI, real time",
author = "Han, {Seunggu (Jude)} and Krystof Bankiewicz and Butowski, {Nicholas A.} and Larson, {Paul S.} and Aghi, {Manish K.}",
year = "2016",
month = "6",
day = "2",
doi = "10.1080/14737175.2016.1175939",
language = "English (US)",
volume = "16",
pages = "635--639",
journal = "Expert Review of Neurotherapeutics",
issn = "1473-7175",
publisher = "Expert Reviews Ltd.",
number = "6",

}

TY - JOUR

T1 - Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system

AU - Han, Seunggu (Jude)

AU - Bankiewicz, Krystof

AU - Butowski, Nicholas A.

AU - Larson, Paul S.

AU - Aghi, Manish K.

PY - 2016/6/2

Y1 - 2016/6/2

N2 - Local delivery of therapeutic agents into the brain has many advantages; however, the inability to predict, visualize and confirm the infusion into the intended target has been a major hurdle in its clinical development. Here, we describe the current workflow and application of the interventional MRI (iMRI) system for catheter placement and real time visualization of infusion. We have applied real time convection-enhanced delivery (CED) of therapeutic agents with iMRI across a number of different clinical trials settings in neuro-oncology and movement disorders. Ongoing developments and accumulating experience with the technique and technology of drug formulations, CED platforms, and iMRI systems will continue to make local therapeutic delivery into the brain more accurate, efficient, effective and safer.

AB - Local delivery of therapeutic agents into the brain has many advantages; however, the inability to predict, visualize and confirm the infusion into the intended target has been a major hurdle in its clinical development. Here, we describe the current workflow and application of the interventional MRI (iMRI) system for catheter placement and real time visualization of infusion. We have applied real time convection-enhanced delivery (CED) of therapeutic agents with iMRI across a number of different clinical trials settings in neuro-oncology and movement disorders. Ongoing developments and accumulating experience with the technique and technology of drug formulations, CED platforms, and iMRI systems will continue to make local therapeutic delivery into the brain more accurate, efficient, effective and safer.

KW - catheter placement

KW - convection enhanced delivery

KW - drug delivery

KW - Interventional MRI

KW - real time

UR - http://www.scopus.com/inward/record.url?scp=84964497462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964497462&partnerID=8YFLogxK

U2 - 10.1080/14737175.2016.1175939

DO - 10.1080/14737175.2016.1175939

M3 - Article

VL - 16

SP - 635

EP - 639

JO - Expert Review of Neurotherapeutics

JF - Expert Review of Neurotherapeutics

SN - 1473-7175

IS - 6

ER -