Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT

Marcelo Souto Nacif, Nadine Kawel, Jason J. Lee, Xinjian Chen, Jianhua Yao, Anna Zavodni, Christopher Sibley, João A C Lima, Songtao Liu, David A. Bluemke

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Purpose: To develop a cardiac computed tomographic (CT) method with which to determine extracellular volume (ECV) fraction, with cardiac magnetic resonance (MR) imaging as the reference standard. Materials and Methods: Study participants provided written informed consent to participate in this institutional review board-approved study. ECV was measured in healthy subjects and patients with heart failure by using cardiac CT and cardiac MR imaging. Paired Student t test, linear regression analysis, and Pearson correlation analysis were used to determine the relationship between cardiac CT and MR imaging ECV values and clinical parameters. Results: Twenty-four subjects were studied. There was good correlation between myocardial ECV measured at cardiac MR imaging and that measured at cardiac CT (r = 0.82, P <.001). As expected, ECV was higher in patients with heart failure than in healthy control subjects for both cardiac CT and cardiac MR imaging (P = .03, respectively). For both cardiac MR imaging and cardiac CT, ECV was positively associated with end diastolic and end systolic volume and inversely related to ejection fraction (P <.05 for all). Mean radiation dose was 1.98 mSv ± 0.16 (standard deviation) for each cardiac CT acquisition. Conclusion: ECV at cardiac CT and that at cardiac MR imaging showed good correlation, suggesting the potential for myocardial tissue characterization with cardiac CT.

Original languageEnglish (US)
Pages (from-to)876-883
Number of pages8
JournalRadiology
Volume264
Issue number3
DOIs
StatePublished - Sep 2012
Externally publishedYes

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Fibrosis
Magnetic Resonance Imaging
Radiation
Healthy Volunteers
Heart Failure
Cardiac Volume
Research Ethics Committees
Informed Consent
Linear Models
Regression Analysis
Students

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Nacif, M. S., Kawel, N., Lee, J. J., Chen, X., Yao, J., Zavodni, A., ... Bluemke, D. A. (2012). Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT. Radiology, 264(3), 876-883. https://doi.org/10.1148/radiol.12112458

Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT. / Nacif, Marcelo Souto; Kawel, Nadine; Lee, Jason J.; Chen, Xinjian; Yao, Jianhua; Zavodni, Anna; Sibley, Christopher; Lima, João A C; Liu, Songtao; Bluemke, David A.

In: Radiology, Vol. 264, No. 3, 09.2012, p. 876-883.

Research output: Contribution to journalArticle

Nacif, MS, Kawel, N, Lee, JJ, Chen, X, Yao, J, Zavodni, A, Sibley, C, Lima, JAC, Liu, S & Bluemke, DA 2012, 'Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT', Radiology, vol. 264, no. 3, pp. 876-883. https://doi.org/10.1148/radiol.12112458
Nacif, Marcelo Souto ; Kawel, Nadine ; Lee, Jason J. ; Chen, Xinjian ; Yao, Jianhua ; Zavodni, Anna ; Sibley, Christopher ; Lima, João A C ; Liu, Songtao ; Bluemke, David A. / Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT. In: Radiology. 2012 ; Vol. 264, No. 3. pp. 876-883.
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