Interpretation of flood-illuminated adaptive optics images in subjects with Retinitis Pigmentosa

Michael J. Gale, Shu Feng, Hope E. Titus, Travis Smith, Mark Pennesi

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

The purpose of this study was to correlate features on flood-illuminated adaptive optics (AO) images with color fundus, fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) images in patients with retinitis pigmentosa (RP). We imaged 39 subjects diagnosed with RP using the rtx1TM flood-illuminated AO camera from Imagine Eyes (Orsay, France). We observed a correlation between hyper-autofluoresence changes on FAF, disruption of the interdigitation zone (IZ) on SD-OCT and loss of reflective cone profiles on AO. Four main patterns of cone-reflectivity were seen on AO: presumed healthy cone mosaics, hypo-reflective blurred cone-like structures, higher frequency disorganized hyper-reflective spots, and lower frequency hypo-reflective spots. These regions were correlated to progressive phases of cone photoreceptor degeneration observed using SD-OCT and FAF. These results help provide interpretation of en face images obtained by flood-illuminated AO in subjects with RP. However, significant ambiguity remains as to what truly constitutes a cone, especially in areas of degeneration. With further refinements in technology, flood illuminated AO imaging has the potential to provide rapid, standardized, longitudinal and lower cost imaging in patients with retinal degeneration.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages291-297
Number of pages7
Volume854
DOIs
StatePublished - Oct 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume854
ISSN (Print)00652598
ISSN (Electronic)22148019

Fingerprint

Retinitis Pigmentosa
Adaptive optics
Cones
Optical Coherence Tomography
Optical tomography
Retinal Cone Photoreceptor Cells
Retinal Degeneration
France
Imaging techniques
Color
Technology
Costs and Cost Analysis
Cameras
Costs

Keywords

  • Cone photoreceptors
  • Flood
  • Illuminated adaptive optics
  • Multimodal imaging
  • Retinal degeneration
  • Retinitis pigmentosa

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Gale, M. J., Feng, S., Titus, H. E., Smith, T., & Pennesi, M. (2016). Interpretation of flood-illuminated adaptive optics images in subjects with Retinitis Pigmentosa. In Advances in Experimental Medicine and Biology (Vol. 854, pp. 291-297). (Advances in Experimental Medicine and Biology; Vol. 854). Springer New York LLC. https://doi.org/10.1007/978-3-319-17121-0_39

Interpretation of flood-illuminated adaptive optics images in subjects with Retinitis Pigmentosa. / Gale, Michael J.; Feng, Shu; Titus, Hope E.; Smith, Travis; Pennesi, Mark.

Advances in Experimental Medicine and Biology. Vol. 854 Springer New York LLC, 2016. p. 291-297 (Advances in Experimental Medicine and Biology; Vol. 854).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gale, MJ, Feng, S, Titus, HE, Smith, T & Pennesi, M 2016, Interpretation of flood-illuminated adaptive optics images in subjects with Retinitis Pigmentosa. in Advances in Experimental Medicine and Biology. vol. 854, Advances in Experimental Medicine and Biology, vol. 854, Springer New York LLC, pp. 291-297. https://doi.org/10.1007/978-3-319-17121-0_39
Gale MJ, Feng S, Titus HE, Smith T, Pennesi M. Interpretation of flood-illuminated adaptive optics images in subjects with Retinitis Pigmentosa. In Advances in Experimental Medicine and Biology. Vol. 854. Springer New York LLC. 2016. p. 291-297. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-17121-0_39
Gale, Michael J. ; Feng, Shu ; Titus, Hope E. ; Smith, Travis ; Pennesi, Mark. / Interpretation of flood-illuminated adaptive optics images in subjects with Retinitis Pigmentosa. Advances in Experimental Medicine and Biology. Vol. 854 Springer New York LLC, 2016. pp. 291-297 (Advances in Experimental Medicine and Biology).
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