Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: Implications for human breast cancer

S. M. Pontier; L. Huck; D. E. White; J. Rayment; V. Sanguin-Gendreau; B. Hennessy; D. Zuo; R. St-Arnaud; Gordon Mills; S. Dedhar; C. J. Marshall; W. J. Muller

doi:10.1038/onc.2010.86

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: Implications for human breast cancer

S. M. Pontier, L. Huck, D. E. White, J. Rayment, V. Sanguin-Gendreau, B. Hennessy, D. Zuo, R. St-Arnaud, Gordon Mills, S. Dedhar, C. J. Marshall, W. J. Muller

Research output: Contribution to journal › Article

33 Scopus citations

Abstract

Elevated expression of the integrin-linked kinase (ILK) has been observed in a variety of cancers and has been further correlated with poor clinical outcome. Here, we show that mammary epithelial disruption of ILK results in a profound block in mammary tumor induction. Consistent with these observations, inhibition of ILK function in ErbB2-expressing cells with small molecule inhibitor or RNA interference resulted in profound block in their in vitro invasive properties due to the induction of apoptotic cell death. The rare ILK-deficient tumors that eventually arose overcame this block in tumor induction by an upregulation of ErB3 phosphorylation. These observations provide direct evidence that ILK has a critical role in the initiation phase of ErbB2 tumor induction.

Original language	English (US)
Pages (from-to)	3374-3385
Number of pages	12
Journal	Oncogene
Volume	29
Issue number	23
DOIs	https://doi.org/10.1038/onc.2010.86
Publication status	Published - Jun 10 2010
Externally published	Yes

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Keywords

ErbB2
Integrin-linked kinase
Mammary tumorigenesis

ASJC Scopus subject areas

Molecular Biology
Cancer Research
Genetics

Cite this

Pontier, S. M., Huck, L., White, D. E., Rayment, J., Sanguin-Gendreau, V., Hennessy, B., ... Muller, W. J. (2010). Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: Implications for human breast cancer. Oncogene, 29(23), 3374-3385. https://doi.org/10.1038/onc.2010.86

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression : Implications for human breast cancer. / Pontier, S. M.; Huck, L.; White, D. E.; Rayment, J.; Sanguin-Gendreau, V.; Hennessy, B.; Zuo, D.; St-Arnaud, R.; Mills, Gordon; Dedhar, S.; Marshall, C. J.; Muller, W. J.

In: Oncogene, Vol. 29, No. 23, 10.06.2010, p. 3374-3385.

Research output: Contribution to journal › Article

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10.1038/onc.2010.86