Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics

Kevin M. Kelley, Youngman Oh, Sharron E. Gargosky, Zoran Gucev, Tomoko Matsumoto, Vivian Hwa, Lilly Ng, Diane M. Simpson, Ron G. Rosenfeld

Research output: Contribution to journalReview article

381 Scopus citations

Abstract

The IGFBPs are a family of homologous proteins that have co-evolved with the IGFs and that confer upon the IGF regulatory system both functional and tissue specificity. IGFBPs are not merely carrier proteins for IGFs, but hold a central position in IGF ligand-receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. In addition, IGFBPs appear to have intrinsic biological activity independent of IGFs. The current status of research on IGFBPs is reviewed herein. Following a brief introduction to the entire IGF/IGFBP system, separate sections for each of the six cloned mammalian IGFBPs, the most extensive for IGFBP3, cover selected topics that emphasize the dynamics of IGFBPs - that is, their regulation in cells, their functionally important post-translational modifications, and their interactions in the cellular microenvironment-and how these dynamics influence physiological function.

Original languageEnglish (US)
Pages (from-to)619-637
Number of pages19
JournalInternational Journal of Biochemistry and Cell Biology
Volume28
Issue number6
DOIs
StatePublished - Jun 1996

Keywords

  • Cancer
  • Diabetes mellitus
  • Growth regulation
  • IGFBP protease
  • Reproduction

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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    Kelley, K. M., Oh, Y., Gargosky, S. E., Gucev, Z., Matsumoto, T., Hwa, V., Ng, L., Simpson, D. M., & Rosenfeld, R. G. (1996). Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. International Journal of Biochemistry and Cell Biology, 28(6), 619-637. https://doi.org/10.1016/1357-2725(96)00005-2