Initial sensitivity and tolerance to ethanol in mice: correlations among open field activity, hypothermia, and loss of righting reflex

John C. Crabbe, Daniel K. Gray, Emmett R. Young, Jeri S. Janowsky, Henk Rigter

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Abstract

The sensitivity of male Swiss albino mice to the effects of ethanol was successively tested using measures of open field activity (OFA), hypothermia (HT), and duration of loss of righting reflex (LORR). Doses used were 1, 3, and 4.5 g/kg (ip) ethanol. Tests were conducted 1 week apart and were counterbalanced for order. HT was positively correlated with baseline temperature. This could represent a "normalizing" effect of ethanol, or an undetermined common mechanism. HT and degree of subsequent tolerance to HT were highly positively correlated. Baseline OFA was positively correlated with ethanol-induced LORR. LORR also correlated positively with HT, but neither baseline nor ethanol-stimulated OFA were significantly associated with HT.

Original languageEnglish (US)
Pages (from-to)188-203
Number of pages16
JournalBehavioral and Neural Biology
Volume33
Issue number2
DOIs
StatePublished - Oct 1981

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ASJC Scopus subject areas

  • Physiology

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