Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells

Sivalokanathan Sarveswaran, Debrup Chakraborty, Dhananjay Chitale, Rosalie Sears, Jagadananda Ghosh

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background: Frequent overactivation of c-Myc aggravates a spectrum of cancers. However, cancer-specific inhibition of c-Myc activity poses significant difficulty.

Original languageEnglish (US)
Pages (from-to)4994-5006
Number of pages13
JournalJournal of Biological Chemistry
Volume290
Issue number8
DOIs
StatePublished - Feb 20 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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