Abstract
Objective: To examine whether the magnitude of the rise in inhibin B levels after gonadotropin challenge is associated with subsequent response to ovarian stimulation during IVF. Design: Inhibin B serum levels after EFORT (exogenous follicle-stimulating hormone ovarian reserve test). Setting: Academic clinical practice. Patient(s): Serum samples from women who had undergone ovarian reserve screening with FSH in preparation for IVF. Thirteen of these women had a poor response in IVF (canceled cycle for low estradiol and/or no oocytes retrieved), and 19 had a good response (≥10 oocytes retrieved). Intervention(s): EFORT test. Main Outcome Measure(s): Baseline (day 3) serum E2 (bE2), FSH (bFSH), and inhibin B (bInhB) levels and inhibin B and E2 levels 24 hours after EFORT (ΔInhB and ΔE2). Result(s): The mean bInhB and ΔInhB levels were significantly higher in good vs. poor responders. The odds ratio of having a good response for women with a ΔInhB of 202 pg/mL was 51.8 times (95% CI = 6.1-1,244) the corresponding odds for women with a ΔInhB of 49 pg/mL. As expected, ΔE2 was also significantly higher in good vs. poor responders; however, combination of ΔE2 plus ΔInhB did not improve the odds for predicting IVF response. Conclusion(s): Our data suggest that ΔInhB after EFORT may provide a method for predicting ovarian response to hyperstimulation in a subsequent IVF cycle. Copyright (C) 2000 American Society for Reproductive Medicine.
Original language | English (US) |
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Pages (from-to) | 1114-1117 |
Number of pages | 4 |
Journal | Fertility and sterility |
Volume | 74 |
Issue number | 6 |
DOIs | |
State | Published - 2000 |
Externally published | Yes |
Keywords
- EFORT
- Estradiol
- FSH
- IVF
- Inhibin B
- Ovarian reserve
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology