Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle

Artur Dzik, Geralyn Lambert-Messerlian, Vicente Mario Izzo, Jonatas Borges Soares, José Aristodemo Pinotti, David Seifer

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objective: To examine whether the magnitude of the rise in inhibin B levels after gonadotropin challenge is associated with subsequent response to ovarian stimulation during IVF. Design: Inhibin B serum levels after EFORT (exogenous follicle-stimulating hormone ovarian reserve test). Setting: Academic clinical practice. Patient(s): Serum samples from women who had undergone ovarian reserve screening with FSH in preparation for IVF. Thirteen of these women had a poor response in IVF (canceled cycle for low estradiol and/or no oocytes retrieved), and 19 had a good response (≥10 oocytes retrieved). Intervention(s): EFORT test. Main Outcome Measure(s): Baseline (day 3) serum E 2 (bE 2), FSH (bFSH), and inhibin B (bInhB) levels and inhibin B and E 2 levels 24 hours after EFORT (ΔInhB and ΔE 2). Result(s): The mean bInhB and ΔInhB levels were significantly higher in good vs. poor responders. The odds ratio of having a good response for women with a ΔInhB of 202 pg/mL was 51.8 times (95% CI = 6.1-1,244) the corresponding odds for women with a ΔInhB of 49 pg/mL. As expected, ΔE 2 was also significantly higher in good vs. poor responders; however, combination of ΔE 2 plus ΔInhB did not improve the odds for predicting IVF response. Conclusion(s): Our data suggest that ΔInhB after EFORT may provide a method for predicting ovarian response to hyperstimulation in a subsequent IVF cycle. Copyright (C) 2000 American Society for Reproductive Medicine.

Original languageEnglish (US)
Pages (from-to)1114-1117
Number of pages4
JournalFertility and Sterility
Volume74
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Oocyte Retrieval
Follicle Stimulating Hormone
Fertilization in Vitro
Oocytes
Serum
Ovulation Induction
Gonadotropins
Estradiol
Odds Ratio
Outcome Assessment (Health Care)
Ovarian Reserve
inhibin B

Keywords

  • EFORT
  • Estradiol
  • FSH
  • Inhibin B
  • IVF
  • Ovarian reserve

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle. / Dzik, Artur; Lambert-Messerlian, Geralyn; Izzo, Vicente Mario; Soares, Jonatas Borges; Pinotti, José Aristodemo; Seifer, David.

In: Fertility and Sterility, Vol. 74, No. 6, 2000, p. 1114-1117.

Research output: Contribution to journalArticle

Dzik, Artur ; Lambert-Messerlian, Geralyn ; Izzo, Vicente Mario ; Soares, Jonatas Borges ; Pinotti, José Aristodemo ; Seifer, David. / Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle. In: Fertility and Sterility. 2000 ; Vol. 74, No. 6. pp. 1114-1117.
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