Inheritance of chromosome heteromorphisms analyzed by high-resolution bivariate flow karyotyping

B. Trask, G. Van den Engh, Joe Gray

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The DNA content of the mitotic chromosomes from 10 children and their parents in four families were quantified by bivariate flow karyotyping. In all cases each chromosome peak in the flow karyotype of the child could be traced to one of the two parents. The measured absolute difference in homologue DNA content between children and their parents averaged 0.8%, or ≃1 Mbp over all chromosome types. This study demonstrates that flow karyotypes of a proband's parents can be an aid in detecting and quantifying the size of de novo deletions that involve heteromorphic chromosome types.

Original languageEnglish (US)
Pages (from-to)753-760
Number of pages8
JournalAmerican Journal of Human Genetics
Volume45
Issue number5
StatePublished - 1989
Externally publishedYes

Fingerprint

Karyotyping
Chromosomes
Parents
Karyotype
Chromosomes, Human, Pair 10
DNA

ASJC Scopus subject areas

  • Genetics

Cite this

Inheritance of chromosome heteromorphisms analyzed by high-resolution bivariate flow karyotyping. / Trask, B.; Van den Engh, G.; Gray, Joe.

In: American Journal of Human Genetics, Vol. 45, No. 5, 1989, p. 753-760.

Research output: Contribution to journalArticle

@article{ade7cff06eaf4373bf8addf8974b01b7,
title = "Inheritance of chromosome heteromorphisms analyzed by high-resolution bivariate flow karyotyping",
abstract = "The DNA content of the mitotic chromosomes from 10 children and their parents in four families were quantified by bivariate flow karyotyping. In all cases each chromosome peak in the flow karyotype of the child could be traced to one of the two parents. The measured absolute difference in homologue DNA content between children and their parents averaged 0.8{\%}, or ≃1 Mbp over all chromosome types. This study demonstrates that flow karyotypes of a proband's parents can be an aid in detecting and quantifying the size of de novo deletions that involve heteromorphic chromosome types.",
author = "B. Trask and {Van den Engh}, G. and Joe Gray",
year = "1989",
language = "English (US)",
volume = "45",
pages = "753--760",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Inheritance of chromosome heteromorphisms analyzed by high-resolution bivariate flow karyotyping

AU - Trask, B.

AU - Van den Engh, G.

AU - Gray, Joe

PY - 1989

Y1 - 1989

N2 - The DNA content of the mitotic chromosomes from 10 children and their parents in four families were quantified by bivariate flow karyotyping. In all cases each chromosome peak in the flow karyotype of the child could be traced to one of the two parents. The measured absolute difference in homologue DNA content between children and their parents averaged 0.8%, or ≃1 Mbp over all chromosome types. This study demonstrates that flow karyotypes of a proband's parents can be an aid in detecting and quantifying the size of de novo deletions that involve heteromorphic chromosome types.

AB - The DNA content of the mitotic chromosomes from 10 children and their parents in four families were quantified by bivariate flow karyotyping. In all cases each chromosome peak in the flow karyotype of the child could be traced to one of the two parents. The measured absolute difference in homologue DNA content between children and their parents averaged 0.8%, or ≃1 Mbp over all chromosome types. This study demonstrates that flow karyotypes of a proband's parents can be an aid in detecting and quantifying the size of de novo deletions that involve heteromorphic chromosome types.

UR - http://www.scopus.com/inward/record.url?scp=0024468930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024468930&partnerID=8YFLogxK

M3 - Article

C2 - 2816941

AN - SCOPUS:0024468930

VL - 45

SP - 753

EP - 760

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 5

ER -