Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas: A series of 67 granulomas

Alexander T. Hillel, Li Mei Lin, Robin Samlan, Heather Starmer, Kevin Leahy, Paul Flint

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objectives: We sought to analyze the outcomes of vocal process granulomas treated with proton pump inhibitors and inhaled triamcinolone acetonide. Methods: We reviewed the medical records of patients with a diagnosis of contact granuloma or vocal process granuloma between 1995 and 2008. Data included age, gender, intubation history, reflux history, lesion location, previous treatment methods, treatment course, and recurrence. All patients were treated with daily or twice-daily protein pump inhibitors and inhaled triamcinolone acetonide (300 μg 3 times a day). Results: Sixty-seven granulomas were diagnosed in 54 patients: 13 bilateral and 41 unilateral. Twenty patients, including all 11 women, had a recent history of intubation. Sixty-two granulomas in 50 patients were treated with triamcinolone and a proton pump inhibitor. Of the 57 granulomas that completed treatment, 5 (9%) did not respond (mean follow-up, 50 weeks; range, 30.3 to 78.3 weeks), 13 (22%) partially responded (mean follow-up, 11 weeks; range, 3 to 30 weeks), and 40 (69%) completely responded (mean follow-up, 21 weeks; range, 5.9 to 84.6 weeks). Three cases had recurrence: 2 nonresponders and 1 complete responder. One patient developed oral thrush. Conclusions: In this study, vocal process granulomas occurred more frequently in men, whereas women developed granulomas only after intubation. The anti-inflammatory action of inhaled triamcinolone combined with antireflux proton pump inhibitors successfully treats most vocal process granulomas with low rates of side effects and recurrence.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
JournalAnnals of Otology, Rhinology and Laryngology
Volume119
Issue number5
StatePublished - May 2010
Externally publishedYes

Fingerprint

Triamcinolone
Proton Pump Inhibitors
Granuloma
Intubation
Triamcinolone Acetonide
Therapeutics
Recurrence
History
Oral Candidiasis
Medical Records
Anti-Inflammatory Agents

Keywords

  • Gastroesophageal reflux
  • Hyperfunctional voice abuse
  • Inhaled steroid
  • Proton pump inhibitor
  • Speech therapy
  • Vocal process granuloma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas : A series of 67 granulomas. / Hillel, Alexander T.; Lin, Li Mei; Samlan, Robin; Starmer, Heather; Leahy, Kevin; Flint, Paul.

In: Annals of Otology, Rhinology and Laryngology, Vol. 119, No. 5, 05.2010, p. 325-330.

Research output: Contribution to journalArticle

Hillel, Alexander T. ; Lin, Li Mei ; Samlan, Robin ; Starmer, Heather ; Leahy, Kevin ; Flint, Paul. / Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas : A series of 67 granulomas. In: Annals of Otology, Rhinology and Laryngology. 2010 ; Vol. 119, No. 5. pp. 325-330.
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