Influence of topically applied adrenergic agents on cochlear blood flow

K. A. Ohlsen, D. L. Baldwin, Alfred Nuttall, J. M. Miller

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

This study was designed to assess the role of adrenergic receptors in the control of cochlear blood flow. Laser Doppler flowmetry was used to determine the effects of adrenergic drugs topically applied to the round window membrane of the cochlea. The relative influence of the various receptor types (α1, α2, β1, and β2) was examined by a selection of agonists and antagonists. The agonits norepinephrine and epinephrine, which have mixed α- and β-receptor effects, and phenylephrine, a strong α1-agonist, all induced a dose-dependent reduction in cochlear blood flow. The agonists isoproterenol (β-active), salbutamol (β2-active), and BHT 933 (α2-active) had no effect on cochlear blood flow. Of the antagonists, when tested alone, only the selective α1-antagonist prazosin had a direct effect on cochlear blood flow, demonstrating an increase in cochlear blood flow. The selective α2-antagonist idazoxan, the β-antagonist propranolol, and the unselective α-antagonist phentolamine had no effect on cochlear blood flow. Interaction studies of agonists and antagonists were performed to specifically define the receptor subclasses responsible for the cochlear blood flow increases with norepinephrine and epinephrine. The results are consistent with the presence of an α1-adrenergic sympathetic control of cochlear blood flow.

Original languageEnglish (US)
Pages (from-to)509-518
Number of pages10
JournalCirculation Research
Volume69
Issue number2
StatePublished - 1991
Externally publishedYes

Fingerprint

Cochlea
Adrenergic Agents
Epinephrine
Norepinephrine
Idazoxan
Laser-Doppler Flowmetry
Albuterol
Prazosin
Phentolamine
Phenylephrine
Isoproterenol
Propranolol
Adrenergic Receptors
Membranes

Keywords

  • α-receptors
  • β-receptors
  • Blood pressure
  • Guinea pigs
  • Laser Doppler flowmetry
  • Vasoconstrictors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Ohlsen, K. A., Baldwin, D. L., Nuttall, A., & Miller, J. M. (1991). Influence of topically applied adrenergic agents on cochlear blood flow. Circulation Research, 69(2), 509-518.

Influence of topically applied adrenergic agents on cochlear blood flow. / Ohlsen, K. A.; Baldwin, D. L.; Nuttall, Alfred; Miller, J. M.

In: Circulation Research, Vol. 69, No. 2, 1991, p. 509-518.

Research output: Contribution to journalArticle

Ohlsen, KA, Baldwin, DL, Nuttall, A & Miller, JM 1991, 'Influence of topically applied adrenergic agents on cochlear blood flow', Circulation Research, vol. 69, no. 2, pp. 509-518.
Ohlsen, K. A. ; Baldwin, D. L. ; Nuttall, Alfred ; Miller, J. M. / Influence of topically applied adrenergic agents on cochlear blood flow. In: Circulation Research. 1991 ; Vol. 69, No. 2. pp. 509-518.
@article{2c0083c81147402db157f2568f8f702c,
title = "Influence of topically applied adrenergic agents on cochlear blood flow",
abstract = "This study was designed to assess the role of adrenergic receptors in the control of cochlear blood flow. Laser Doppler flowmetry was used to determine the effects of adrenergic drugs topically applied to the round window membrane of the cochlea. The relative influence of the various receptor types (α1, α2, β1, and β2) was examined by a selection of agonists and antagonists. The agonits norepinephrine and epinephrine, which have mixed α- and β-receptor effects, and phenylephrine, a strong α1-agonist, all induced a dose-dependent reduction in cochlear blood flow. The agonists isoproterenol (β-active), salbutamol (β2-active), and BHT 933 (α2-active) had no effect on cochlear blood flow. Of the antagonists, when tested alone, only the selective α1-antagonist prazosin had a direct effect on cochlear blood flow, demonstrating an increase in cochlear blood flow. The selective α2-antagonist idazoxan, the β-antagonist propranolol, and the unselective α-antagonist phentolamine had no effect on cochlear blood flow. Interaction studies of agonists and antagonists were performed to specifically define the receptor subclasses responsible for the cochlear blood flow increases with norepinephrine and epinephrine. The results are consistent with the presence of an α1-adrenergic sympathetic control of cochlear blood flow.",
keywords = "α-receptors, β-receptors, Blood pressure, Guinea pigs, Laser Doppler flowmetry, Vasoconstrictors",
author = "Ohlsen, {K. A.} and Baldwin, {D. L.} and Alfred Nuttall and Miller, {J. M.}",
year = "1991",
language = "English (US)",
volume = "69",
pages = "509--518",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Influence of topically applied adrenergic agents on cochlear blood flow

AU - Ohlsen, K. A.

AU - Baldwin, D. L.

AU - Nuttall, Alfred

AU - Miller, J. M.

PY - 1991

Y1 - 1991

N2 - This study was designed to assess the role of adrenergic receptors in the control of cochlear blood flow. Laser Doppler flowmetry was used to determine the effects of adrenergic drugs topically applied to the round window membrane of the cochlea. The relative influence of the various receptor types (α1, α2, β1, and β2) was examined by a selection of agonists and antagonists. The agonits norepinephrine and epinephrine, which have mixed α- and β-receptor effects, and phenylephrine, a strong α1-agonist, all induced a dose-dependent reduction in cochlear blood flow. The agonists isoproterenol (β-active), salbutamol (β2-active), and BHT 933 (α2-active) had no effect on cochlear blood flow. Of the antagonists, when tested alone, only the selective α1-antagonist prazosin had a direct effect on cochlear blood flow, demonstrating an increase in cochlear blood flow. The selective α2-antagonist idazoxan, the β-antagonist propranolol, and the unselective α-antagonist phentolamine had no effect on cochlear blood flow. Interaction studies of agonists and antagonists were performed to specifically define the receptor subclasses responsible for the cochlear blood flow increases with norepinephrine and epinephrine. The results are consistent with the presence of an α1-adrenergic sympathetic control of cochlear blood flow.

AB - This study was designed to assess the role of adrenergic receptors in the control of cochlear blood flow. Laser Doppler flowmetry was used to determine the effects of adrenergic drugs topically applied to the round window membrane of the cochlea. The relative influence of the various receptor types (α1, α2, β1, and β2) was examined by a selection of agonists and antagonists. The agonits norepinephrine and epinephrine, which have mixed α- and β-receptor effects, and phenylephrine, a strong α1-agonist, all induced a dose-dependent reduction in cochlear blood flow. The agonists isoproterenol (β-active), salbutamol (β2-active), and BHT 933 (α2-active) had no effect on cochlear blood flow. Of the antagonists, when tested alone, only the selective α1-antagonist prazosin had a direct effect on cochlear blood flow, demonstrating an increase in cochlear blood flow. The selective α2-antagonist idazoxan, the β-antagonist propranolol, and the unselective α-antagonist phentolamine had no effect on cochlear blood flow. Interaction studies of agonists and antagonists were performed to specifically define the receptor subclasses responsible for the cochlear blood flow increases with norepinephrine and epinephrine. The results are consistent with the presence of an α1-adrenergic sympathetic control of cochlear blood flow.

KW - α-receptors

KW - β-receptors

KW - Blood pressure

KW - Guinea pigs

KW - Laser Doppler flowmetry

KW - Vasoconstrictors

UR - http://www.scopus.com/inward/record.url?scp=0025875715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025875715&partnerID=8YFLogxK

M3 - Article

VL - 69

SP - 509

EP - 518

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 2

ER -