Influence of suckling on gonadotropin secretion in the female rhesus monkey (Macaca mulatta)

T. M. Plant, E. Schallenberger, D. L. Hess, J. T. McCormack, L. Dufy-Barbe, E. Knobil

    Research output: Contribution to journalArticle

    30 Scopus citations

    Abstract

    The ability of exogenous estrogen to elicit gonadotropin surges was determined at approximately monthly intervals in postpartum female rhesus monkeys nursing their infants, in postpartum females whose infants were weaned at birth, and in pregestational females that served as foster mothers to these weaned infants. The stimulatory action of estrogen on gonadotropin secretion was abolished or severely inhibited for the first 6 months of nursing in both natural and foster mothers. In contrast, the administration of estrogen to postpartum females, whose infants were weaned at birth, elicited luteining hormone (LH) and follicle stimulating hormone (FSH) surgers on the first trial 30 days after delivery. The abolition of the positive feedback action of estrogen in nursing mothers was associated with a suppression of basal serum gonadotropin levels. These findings demonstrate that the protracted inhibition of gonadotropin secretion in lactating female rhesus monkeys is occassioned by the presence of a suckling infant and is independent of antecedent events associated with gestation and parturition.

    Original languageEnglish (US)
    Pages (from-to)760-766
    Number of pages7
    JournalBiology of reproduction
    Volume23
    Issue number4
    DOIs
    StatePublished - Dec 1 1980

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Cell Biology

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  • Cite this

    Plant, T. M., Schallenberger, E., Hess, D. L., McCormack, J. T., Dufy-Barbe, L., & Knobil, E. (1980). Influence of suckling on gonadotropin secretion in the female rhesus monkey (Macaca mulatta). Biology of reproduction, 23(4), 760-766. https://doi.org/10.1095/biolreprod23.4.760