Influence of pentobarbital on synaptic plasma membrane protein synthesis

Robert Hitzemann, Horace H. Loh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effects of acute and chronic pentobarbital treatment on the incorporation of 3H-lysine into rat brain synaptic plasma membranes (SPM) were examined by means of SDS polyacrylamide gel electrophoresis. The data suggest the major effects of both drug treatments are found in a unique population of SPM derived from a light population of nerve ending particles (NEP). These light NEP preferentially accumulate labelled GABA, suggesting this fraction is enriched in GABA containing nerve terminals.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalLife Sciences
Volume20
Issue number1
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

Fingerprint

Synaptic Membranes
Nerve Endings
Pentobarbital
Cell membranes
gamma-Aminobutyric Acid
Blood Proteins
Membrane Proteins
Cell Membrane
Drug therapy
Light
Electrophoresis
Population
Lysine
Rats
Polyacrylamide Gel Electrophoresis
Brain
Pharmaceutical Preparations
polyacrylamide gels

ASJC Scopus subject areas

  • Pharmacology

Cite this

Influence of pentobarbital on synaptic plasma membrane protein synthesis. / Hitzemann, Robert; Loh, Horace H.

In: Life Sciences, Vol. 20, No. 1, 01.01.1977, p. 35-41.

Research output: Contribution to journalArticle

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