Influence of developmental auditory deprivation on neuronal ultrastructure in the mouse anteroventral cochlear nucleus

Dennis R. Trune; Chris R. Morgan

doi:10.1016/0165-3806(88)90249-0

Influence of developmental auditory deprivation on neuronal ultrastructure in the mouse anteroventral cochlear nucleus

Dennis R. Trune, Chris R. Morgan

Otolaryngology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Developmental auditory deprivation caused mouse anteroventral cochlear nucleus neurons to have significantly fewer auditory nerve terminals and more non-auditory nerve terminals. This suggested that stimulation regulated the developmental arborization of auditory nerve terminals and competition for synaptic space. Intracellularly, mitochondria were smaller and darker in the deprived neurons and appeared less active metabolically. Interference with these neuronal processes may underlie the impaired development seen in auditory deprivation.

Original language	English (US)
Pages (from-to)	304-308
Number of pages	5
Journal	Developmental Brain Research
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(88)90249-0
State	Published - Aug 1 1988

Keywords

Auditory deprivation
Cochlear nucleus
Development
Genetic expression
Metabolism
Morphometry
Neuronal organelle
Synaptic competition

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(88)90249-0

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title = "Influence of developmental auditory deprivation on neuronal ultrastructure in the mouse anteroventral cochlear nucleus",

abstract = "Developmental auditory deprivation caused mouse anteroventral cochlear nucleus neurons to have significantly fewer auditory nerve terminals and more non-auditory nerve terminals. This suggested that stimulation regulated the developmental arborization of auditory nerve terminals and competition for synaptic space. Intracellularly, mitochondria were smaller and darker in the deprived neurons and appeared less active metabolically. Interference with these neuronal processes may underlie the impaired development seen in auditory deprivation.",

keywords = "Auditory deprivation, Cochlear nucleus, Development, Genetic expression, Metabolism, Morphometry, Neuronal organelle, Synaptic competition",

author = "Trune, {Dennis R.} and Morgan, {Chris R.}",

note = "Funding Information: Ms. Jackie Gellatly provided technical assistance in electron microscopy and photography. This research was supported in part by The Deafness Research Foundation, The Medical Research Foundation of Oregon, and BRSG S07 RR05412 Award by the Biomedical Research Support Grant Program, Division of Research Resources, National Institutes of Health.",

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AU - Morgan, Chris R.

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AB - Developmental auditory deprivation caused mouse anteroventral cochlear nucleus neurons to have significantly fewer auditory nerve terminals and more non-auditory nerve terminals. This suggested that stimulation regulated the developmental arborization of auditory nerve terminals and competition for synaptic space. Intracellularly, mitochondria were smaller and darker in the deprived neurons and appeared less active metabolically. Interference with these neuronal processes may underlie the impaired development seen in auditory deprivation.

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KW - Genetic expression

KW - Metabolism

KW - Morphometry

KW - Neuronal organelle

KW - Synaptic competition

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Influence of developmental auditory deprivation on neuronal ultrastructure in the mouse anteroventral cochlear nucleus

Abstract

Keywords

ASJC Scopus subject areas

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