Influence of developmental auditory deprivation on neuronal ultrastructure in the mouse anteroventral cochlear nucleus

Dennis R. Trune, Chris R. Morgan

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Developmental auditory deprivation caused mouse anteroventral cochlear nucleus neurons to have significantly fewer auditory nerve terminals and more non-auditory nerve terminals. This suggested that stimulation regulated the developmental arborization of auditory nerve terminals and competition for synaptic space. Intracellularly, mitochondria were smaller and darker in the deprived neurons and appeared less active metabolically. Interference with these neuronal processes may underlie the impaired development seen in auditory deprivation.

Original languageEnglish (US)
Pages (from-to)304-308
Number of pages5
JournalDevelopmental Brain Research
Volume42
Issue number2
DOIs
StatePublished - Aug 1 1988

Keywords

  • Auditory deprivation
  • Cochlear nucleus
  • Development
  • Genetic expression
  • Metabolism
  • Morphometry
  • Neuronal organelle
  • Synaptic competition

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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