Inflammation, proteases and cancer

Léon C L van Kempen, Karin E. de Visser, Lisa Coussens

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Tumours are complex tissues composed of ever-evolving neoplastic cells, matrix proteins that provide structural support and sequester biologically active molecules, and a cellular stromal component. Reciprocal interactions between neoplastic cells, activated host cells and the dynamic micro-environment in which they live enables tumour growth and dissemination. It has become evident that early and persistent inflammatory responses observed in or around developing neoplasms regulates many aspects of tumour development (matrix remodelling, angiogenesis, malignant potential) by providing diverse mediators implicated in maintaining tissue homeostasis, e.g., soluble growth and survival factors, matrix remodelling enzymes, reactive oxygen species and other bioactive molecules. This review highlights recent insights into the role of chronic inflammation associated with cancer development and examines proteolytic pathways activated by infiltrating leukocytes during neoplastic programming of tissues.

Original languageEnglish (US)
Pages (from-to)728-734
Number of pages7
JournalEuropean Journal of Cancer
Volume42
Issue number6
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Peptide Hydrolases
Inflammation
Neoplasms
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins
Leukocytes
Homeostasis
Enzymes
Growth
Proteins

Keywords

  • Adaptive immunity
  • Angiogenesis
  • Cancer
  • Innate immunity
  • Proteinases
  • Stroma
  • Tumour micro-environment

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Inflammation, proteases and cancer. / van Kempen, Léon C L; de Visser, Karin E.; Coussens, Lisa.

In: European Journal of Cancer, Vol. 42, No. 6, 04.2006, p. 728-734.

Research output: Contribution to journalArticle

van Kempen, Léon C L ; de Visser, Karin E. ; Coussens, Lisa. / Inflammation, proteases and cancer. In: European Journal of Cancer. 2006 ; Vol. 42, No. 6. pp. 728-734.
@article{21d7220cfcf1426f827a2b42c3ac5eb5,
title = "Inflammation, proteases and cancer",
abstract = "Tumours are complex tissues composed of ever-evolving neoplastic cells, matrix proteins that provide structural support and sequester biologically active molecules, and a cellular stromal component. Reciprocal interactions between neoplastic cells, activated host cells and the dynamic micro-environment in which they live enables tumour growth and dissemination. It has become evident that early and persistent inflammatory responses observed in or around developing neoplasms regulates many aspects of tumour development (matrix remodelling, angiogenesis, malignant potential) by providing diverse mediators implicated in maintaining tissue homeostasis, e.g., soluble growth and survival factors, matrix remodelling enzymes, reactive oxygen species and other bioactive molecules. This review highlights recent insights into the role of chronic inflammation associated with cancer development and examines proteolytic pathways activated by infiltrating leukocytes during neoplastic programming of tissues.",
keywords = "Adaptive immunity, Angiogenesis, Cancer, Innate immunity, Proteinases, Stroma, Tumour micro-environment",
author = "{van Kempen}, {L{\'e}on C L} and {de Visser}, {Karin E.} and Lisa Coussens",
year = "2006",
month = "4",
doi = "10.1016/j.ejca.2006.01.004",
language = "English (US)",
volume = "42",
pages = "728--734",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Inflammation, proteases and cancer

AU - van Kempen, Léon C L

AU - de Visser, Karin E.

AU - Coussens, Lisa

PY - 2006/4

Y1 - 2006/4

N2 - Tumours are complex tissues composed of ever-evolving neoplastic cells, matrix proteins that provide structural support and sequester biologically active molecules, and a cellular stromal component. Reciprocal interactions between neoplastic cells, activated host cells and the dynamic micro-environment in which they live enables tumour growth and dissemination. It has become evident that early and persistent inflammatory responses observed in or around developing neoplasms regulates many aspects of tumour development (matrix remodelling, angiogenesis, malignant potential) by providing diverse mediators implicated in maintaining tissue homeostasis, e.g., soluble growth and survival factors, matrix remodelling enzymes, reactive oxygen species and other bioactive molecules. This review highlights recent insights into the role of chronic inflammation associated with cancer development and examines proteolytic pathways activated by infiltrating leukocytes during neoplastic programming of tissues.

AB - Tumours are complex tissues composed of ever-evolving neoplastic cells, matrix proteins that provide structural support and sequester biologically active molecules, and a cellular stromal component. Reciprocal interactions between neoplastic cells, activated host cells and the dynamic micro-environment in which they live enables tumour growth and dissemination. It has become evident that early and persistent inflammatory responses observed in or around developing neoplasms regulates many aspects of tumour development (matrix remodelling, angiogenesis, malignant potential) by providing diverse mediators implicated in maintaining tissue homeostasis, e.g., soluble growth and survival factors, matrix remodelling enzymes, reactive oxygen species and other bioactive molecules. This review highlights recent insights into the role of chronic inflammation associated with cancer development and examines proteolytic pathways activated by infiltrating leukocytes during neoplastic programming of tissues.

KW - Adaptive immunity

KW - Angiogenesis

KW - Cancer

KW - Innate immunity

KW - Proteinases

KW - Stroma

KW - Tumour micro-environment

UR - http://www.scopus.com/inward/record.url?scp=33645998744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645998744&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2006.01.004

DO - 10.1016/j.ejca.2006.01.004

M3 - Article

C2 - 16524717

AN - SCOPUS:33645998744

VL - 42

SP - 728

EP - 734

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 6

ER -