Infection Risk and Safety of Corticosteroid Use

Jameel Youssef, Shannon A. Novosad, Kevin Winthrop

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Corticosteroids are frequently used to treat rheumatic diseases. Their use comes with several well-established risks, including osteoporosis, avascular necrosis, glaucoma, and diabetes. The risk of infection is of utmost concern and is well documented, although randomized controlled3/25/2016 3:35:37 PM trials of short-term and lower-dose steroids have generally shown little or no increased risk. Observational studies from the real world, however, have consistently shown dose-dependent increases in risk for serious infections as well as certain opportunistic infections. In patients who begin chronic steroid therapy, vaccination and screening strategies should be used in an attempt to mitigate this risk.

Original languageEnglish (US)
Pages (from-to)157-176
Number of pages20
JournalRheumatic Disease Clinics of North America
Volume42
Issue number1
DOIs
StatePublished - 2016

Fingerprint

Adrenal Cortex Hormones
Safety
Infection
Steroids
Opportunistic Infections
Rheumatic Diseases
Glaucoma
Osteoporosis
Observational Studies
Vaccination
Necrosis
Therapeutics

Keywords

  • Bacterial infections
  • Corticosteroids
  • Opportunistic infections
  • Rheumatic diseases

ASJC Scopus subject areas

  • Rheumatology

Cite this

Infection Risk and Safety of Corticosteroid Use. / Youssef, Jameel; Novosad, Shannon A.; Winthrop, Kevin.

In: Rheumatic Disease Clinics of North America, Vol. 42, No. 1, 2016, p. 157-176.

Research output: Contribution to journalArticle

Youssef, Jameel ; Novosad, Shannon A. ; Winthrop, Kevin. / Infection Risk and Safety of Corticosteroid Use. In: Rheumatic Disease Clinics of North America. 2016 ; Vol. 42, No. 1. pp. 157-176.
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