TY - JOUR
T1 - Induction of reverse flow of Na+ through the active transport pathway in toad urinary bladder
AU - Dawson, D. C.
AU - Al-Awqati, Q.
N1 - Funding Information:
In a recent study Wolff and Essig \[22\]o btained evidence for a net flow of Na* from serosa to mucosa through Na÷-transporting cells of the toad blad~ier bathed on both sides by Na÷-Ringer's solution and voltage-clamped at a serosal-positiveP D which exceeded the apparent e.m.f, of the active path. This research was supported by grants from the National Institutes of Health (AM18776 and HL19071) and the Iowa Heart Association (76-G-6 and 76-G-1).
PY - 1978/4/4
Y1 - 1978/4/4
N2 - When active Na+ transport across the toad urinary bladder was abolished by ouabain, a 'reversed' short circuit current could be induced by an Na+ concentration gradient. This reversed current was increased by vasopressin and inhibited by amiloride and appears to represent net Na+ movement 'backwards' through epithelial cells which normally participate in active Na+ transport across the bladder.
AB - When active Na+ transport across the toad urinary bladder was abolished by ouabain, a 'reversed' short circuit current could be induced by an Na+ concentration gradient. This reversed current was increased by vasopressin and inhibited by amiloride and appears to represent net Na+ movement 'backwards' through epithelial cells which normally participate in active Na+ transport across the bladder.
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U2 - 10.1016/0005-2736(78)90343-7
DO - 10.1016/0005-2736(78)90343-7
M3 - Article
C2 - 638149
AN - SCOPUS:0017800694
VL - 508
SP - 413
EP - 417
JO - Biochimica et Biophysica Acta - Biomembranes
JF - Biochimica et Biophysica Acta - Biomembranes
SN - 0005-2736
IS - 2
ER -