Indeterminate melanocytic proliferations of the conjunctiva

H. E. Grossniklaus, C. E. Margo, Alvin Jr Solomon, W. R. Green, Jr Eagle R.C., H. E. Grossniklaus

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: The purpose of this study is to test the hypothesis that a subset of conjunctival melanocytic proliferations exists that cannot be reproducibly classified as benign, malignant, or indeterminate. Methods: Three groups of excisional biopsy specimens of conjunctival melanocytic proliferations were evaluated by 5 ophthalmic pathologists. These groups included lesions that were considered by the authors to represent benign (Group 1, n=5), malignant (Group 2, n=5) and indeterminate melanocytic proliferations (Group 3, n=5). The panel classified the same sections in all 3 groups in a randomized, masked fashion, first without and then with a clinical history of patient age, sex and race. The kappa statistic (k) was used to quantify the degree of agreement among observers. Results: There was strong concordance among the panel for both Group 1 (benign, k=0.76) and Group 2 (malignant, k=0.70) melanocytic proliferations. There was no concordance of the panel for Group 3 (indeterminate) lesions (k=-0.045). The concordance for Groups 1 and 2 and lack of concordance for Group 3 lesions were independent of knowledge of clinical history of age, sex, and race. Conclusions: A subset of melanocytic proliferations of the conjunctiva exists that cannot be reproducibly classified by pathologists as benign, malignant, or indeterminate.

Original languageEnglish (US)
Pages (from-to)157-170
Number of pages14
JournalTransactions of the American Ophthalmological Society
Volume97
StatePublished - 1999
Externally publishedYes

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Conjunctiva
Biopsy
Pathologists

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Grossniklaus, H. E., Margo, C. E., Solomon, A. J., Green, W. R., Eagle R.C., J., & Grossniklaus, H. E. (1999). Indeterminate melanocytic proliferations of the conjunctiva. Transactions of the American Ophthalmological Society, 97, 157-170.

Indeterminate melanocytic proliferations of the conjunctiva. / Grossniklaus, H. E.; Margo, C. E.; Solomon, Alvin Jr; Green, W. R.; Eagle R.C., Jr; Grossniklaus, H. E.

In: Transactions of the American Ophthalmological Society, Vol. 97, 1999, p. 157-170.

Research output: Contribution to journalArticle

Grossniklaus, HE, Margo, CE, Solomon, AJ, Green, WR, Eagle R.C., J & Grossniklaus, HE 1999, 'Indeterminate melanocytic proliferations of the conjunctiva', Transactions of the American Ophthalmological Society, vol. 97, pp. 157-170.
Grossniklaus HE, Margo CE, Solomon AJ, Green WR, Eagle R.C. J, Grossniklaus HE. Indeterminate melanocytic proliferations of the conjunctiva. Transactions of the American Ophthalmological Society. 1999;97:157-170.
Grossniklaus, H. E. ; Margo, C. E. ; Solomon, Alvin Jr ; Green, W. R. ; Eagle R.C., Jr ; Grossniklaus, H. E. / Indeterminate melanocytic proliferations of the conjunctiva. In: Transactions of the American Ophthalmological Society. 1999 ; Vol. 97. pp. 157-170.
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