Independent circadian and sleep/wake regulation of adipokines and glucose in humans

Steven Shea, Michael F. Hilton, Christine Orlova, R. Timothy Ayers, Christos S. Mantzoros

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

Leptin and adiponectin play important physiological roles in regulating appetite, food intake, and energy balance and have pathophysiological roles in obesity and anorexia nervosa. To assess the relative contributions of day/night patterns in behaviors (sleep/wake cycle and food intake) and of the endogenous circadian pacemaker on observed day/night patterns of adipokines, in six healthy subjects we measured circulating leptin, soluble leptin receptor, adiponectin, glucose, and insulin levels throughout a constant routine protocol (38 h of wakefulness with constant posture, temperature, and dim light, as well as identical snacks every 2 h) and throughout sleep and fasting periods before and after the constant routine. There were significant endogenous circadian rhythms in leptin, glucose, and insulin, with peaks around the usual time of awakening. Sleep/fasting resulted in additional systematic decreases in leptin, glucose, and insulin, whereas wakefulness/food intake resulted in a systematic increase in leptin. Thus, the day/night pattern in leptin is likely caused by combined effects from the endogenous circadian pacemaker and day/night patterns in behaviors. Our data imply that alterations in the sleep/wake schedule would lead to an increased daily range in circulating leptin, with lowest leptin upon awakening, which, by influencing food intake and energy balance, could be implicated in the increased prevalence of obesity in the shift work population.

Original languageEnglish (US)
Pages (from-to)2537-2544
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume90
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Adipokines
Leptin
Sleep
Glucose
Eating
Pacemakers
Wakefulness
Adiponectin
Insulin
Energy balance
Fasting
Obesity
Leptin Receptors
Snacks
Anorexia Nervosa
Appetite
Circadian Rhythm
Posture
Appointments and Schedules
Healthy Volunteers

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Independent circadian and sleep/wake regulation of adipokines and glucose in humans. / Shea, Steven; Hilton, Michael F.; Orlova, Christine; Timothy Ayers, R.; Mantzoros, Christos S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 5, 05.2005, p. 2537-2544.

Research output: Contribution to journalArticle

Shea, Steven ; Hilton, Michael F. ; Orlova, Christine ; Timothy Ayers, R. ; Mantzoros, Christos S. / Independent circadian and sleep/wake regulation of adipokines and glucose in humans. In: Journal of Clinical Endocrinology and Metabolism. 2005 ; Vol. 90, No. 5. pp. 2537-2544.
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