Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data

Karen Watanabe-Sailor, Mirjana V. Djordjevic, Steven D. Stellman, Patricia L. Toccalino, Donald F. Austin, James F. Pankow

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The manner in which humans smoke cigarettes is an important determinant of smoking risks. Of the few investigators that have predicted cancer risks from smoking on a chemical-specific basis, most used mainstream cigarette smoke (MCS) carcinogen emissions obtained via machine smoking protocols that only approximate human smoking conditions. Here we use data of Djordjevic et al. [Djordjevic, M.V., Stellman, S.D., Zang, E., 2000. Doses of nicotine and lung carcinogens delivered to cigarette smokers. J. Natl. Cancer Inst. 92, 106-111] for MCS emissions of three carcinogens measured under human smoking conditions to compute probability distributions of incremental lifetime cancer risk (ILCR) values using Monte Carlo simulations. The three carcinogens considered are benzo[a]pyrene, N′-nitrosonornicotine (NNN), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Computed NNK ILCR values were compared with lifetime risks of lung cancer (ILCRCMDobsΣ - lung) derived from American Cancer Society Cancer Prevention Studies (CPS) I and II. Within the Monte Carlo simulation results, NNK was responsible for the greatest ILCR values for all cancer endpoints: median ILCR values for NNK were ∼18-fold and 120-fold higher than medians for NNN and benzo[a]pyrene, respectively. For "regular" cigarettes, the NNK median ILCR for lung cancer was lower than ILCRCMDobsΣ - lung from CPS-I and II by >90-fold for men and >4-fold for women. Given what is known about chemical carcinogens in MCS, this study shows that there is a higher incidence of lung cancer from exposure to MCS than can be predicted with current risk assessment methods using available toxicity and emission data.

Original languageEnglish (US)
Pages (from-to)123-133
Number of pages11
JournalRegulatory Toxicology and Pharmacology
Volume55
Issue number2
DOIs
StatePublished - Nov 2009

Fingerprint

Nitrosamines
Tobacco
Benzo(a)pyrene
Smoke
Tobacco Products
Lung Neoplasms
N'-nitrosonornicotine
Carcinogens
Smoking
Neoplasms
Nicotine
Risk assessment
Probability distributions
Toxicity
Research Personnel
Lung
Incidence

Keywords

  • Cancer Prevention Study
  • Cigarette smoking topography
  • Lifetime cancer risk
  • Lung cancer
  • Monte Carlo simulation
  • Tobacco

ASJC Scopus subject areas

  • Toxicology

Cite this

Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data. / Watanabe-Sailor, Karen; Djordjevic, Mirjana V.; Stellman, Steven D.; Toccalino, Patricia L.; Austin, Donald F.; Pankow, James F.

In: Regulatory Toxicology and Pharmacology, Vol. 55, No. 2, 11.2009, p. 123-133.

Research output: Contribution to journalArticle

Watanabe-Sailor, Karen ; Djordjevic, Mirjana V. ; Stellman, Steven D. ; Toccalino, Patricia L. ; Austin, Donald F. ; Pankow, James F. / Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data. In: Regulatory Toxicology and Pharmacology. 2009 ; Vol. 55, No. 2. pp. 123-133.
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