Increased Th17/Treg Ratio in Poststroke Fatigue

Xinjing Liu, Komal Kenkare, Shanshan Li, Varsha Desai, John Wong, Xun Luo, Lisa Wood, Yuming Xu, Qing Mei Wang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Fatigue is a major debilitating symptom after stroke. The biological mechanisms underlying poststroke fatigue (PFS) are unknown. We hypothesized that PSF is associated with an alteration in the balance between Th17 and Treg cells. To test this hypothesis we assessed fatigue in 30 stroke survivors using the Fatigue Scale for Motor and Cognitive Functions (FSMC). Peripheral blood was collected for assessment of Th17 and Treg cell populations and measurement of interleukin-10 (IL-10). Participants were dichotomized into severe fatigue n=14 and low-moderate fatigue n=16 groups by K-mean cluster analysis of FSMC scores. There were no group differences in age, gender, stroke type, stroke severity, or time since stroke. Stroke survivors in the severe fatigue group reported greater anxiety p=0.004 and depression p=0.001 than in the low-moderate fatigue group. The ratio of Th17 to Treg cells was significantly increased in the severe fatigue group relative to the mild-moderate fatigue group p=0.035. Serum levels of IL-10 negatively correlated withTh17/Treg ratio (r=-0.408, p=0.025). Our preliminary findings suggest that an imbalance in the Th17/Treg ratio is associated with the severity of PSF.

Original languageEnglish (US)
Article number931398
JournalMediators of Inflammation
Volume2015
DOIs
StatePublished - 2015
Externally publishedYes

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Fatigue
Stroke
Regulatory T-Lymphocytes
Th17 Cells
Interleukin-10
Cognition
Survivors
Cluster Analysis
Anxiety
Depression
Serum

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Liu, X., Kenkare, K., Li, S., Desai, V., Wong, J., Luo, X., ... Wang, Q. M. (2015). Increased Th17/Treg Ratio in Poststroke Fatigue. Mediators of Inflammation, 2015, [931398]. https://doi.org/10.1155/2015/931398

Increased Th17/Treg Ratio in Poststroke Fatigue. / Liu, Xinjing; Kenkare, Komal; Li, Shanshan; Desai, Varsha; Wong, John; Luo, Xun; Wood, Lisa; Xu, Yuming; Wang, Qing Mei.

In: Mediators of Inflammation, Vol. 2015, 931398, 2015.

Research output: Contribution to journalArticle

Liu, X, Kenkare, K, Li, S, Desai, V, Wong, J, Luo, X, Wood, L, Xu, Y & Wang, QM 2015, 'Increased Th17/Treg Ratio in Poststroke Fatigue', Mediators of Inflammation, vol. 2015, 931398. https://doi.org/10.1155/2015/931398
Liu X, Kenkare K, Li S, Desai V, Wong J, Luo X et al. Increased Th17/Treg Ratio in Poststroke Fatigue. Mediators of Inflammation. 2015;2015. 931398. https://doi.org/10.1155/2015/931398
Liu, Xinjing ; Kenkare, Komal ; Li, Shanshan ; Desai, Varsha ; Wong, John ; Luo, Xun ; Wood, Lisa ; Xu, Yuming ; Wang, Qing Mei. / Increased Th17/Treg Ratio in Poststroke Fatigue. In: Mediators of Inflammation. 2015 ; Vol. 2015.
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