Increased serum prolactin levels mediate the suppressive effects of ectopic pituitary grafts on copulatory behavior in male rats

Paul C. Doherty, Andrzej Bartke, M (Susan) Smith, Steven L. Davis

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To determine if deficits in sexual activity, observed in pituitary-grafted male rats are due to elevated serum prolactin (PRL) levels found in these animals, the effects of whole pituitary grafts, pars distalis grafts, and ovine (o) PRL treatment on male copulatory behavior were compared. Adult sexually experienced CDF male rats were given four whole pituitary grafts, four pars distalis grafts, or were sham operated. Both groups of grafted animals exhibited suppressed copulatory behavior patterns when tested 18 days after pituitary transplantation. Animals given whole pituitary grafts had significantly longer latencies to mount (P <0.05) and to intromit (P <0.01) than did the sham-operated controls, while the animals given anterior pituitary grafts differed from the sham-operated controls in latencies to mount (P <0.05) and to intromit (P <0.01), as well as in the number of intromissions (P <0.05). Prolactin-injected animals had significantly reduced intromission rates (P <0.01) and significantly increased latencies to mount (P <0.05) and to intromit (P <0.01) when compared to vehicle-injected controls. Furthermore, the time course of behavioral suppression was similar in oPRL-treated animals to that observed in pars distalis-grafted males, with both groups showing the onset of deficits in sexual activity within 8 to 9 days from the induction of the hyperprolactinemic state. The similarity in pattern and time to onset of behavioral suppression in pituitary-grafted and oPRL-treated animals suggests that behavioral deficits observed in animals with pituitary grafts result from chronic elevation of serum PRL levels.

Original languageEnglish (US)
Pages (from-to)111-121
Number of pages11
JournalHormones and Behavior
Volume19
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Prolactin
Transplants
Serum
Sexual Behavior
Anterior Pituitary Gland
Sheep
Transplantation

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Increased serum prolactin levels mediate the suppressive effects of ectopic pituitary grafts on copulatory behavior in male rats. / Doherty, Paul C.; Bartke, Andrzej; Smith, M (Susan); Davis, Steven L.

In: Hormones and Behavior, Vol. 19, No. 2, 1985, p. 111-121.

Research output: Contribution to journalArticle

Doherty, Paul C. ; Bartke, Andrzej ; Smith, M (Susan) ; Davis, Steven L. / Increased serum prolactin levels mediate the suppressive effects of ectopic pituitary grafts on copulatory behavior in male rats. In: Hormones and Behavior. 1985 ; Vol. 19, No. 2. pp. 111-121.
@article{6dbcf853a4844565a851df6d124164ef,
title = "Increased serum prolactin levels mediate the suppressive effects of ectopic pituitary grafts on copulatory behavior in male rats",
abstract = "To determine if deficits in sexual activity, observed in pituitary-grafted male rats are due to elevated serum prolactin (PRL) levels found in these animals, the effects of whole pituitary grafts, pars distalis grafts, and ovine (o) PRL treatment on male copulatory behavior were compared. Adult sexually experienced CDF male rats were given four whole pituitary grafts, four pars distalis grafts, or were sham operated. Both groups of grafted animals exhibited suppressed copulatory behavior patterns when tested 18 days after pituitary transplantation. Animals given whole pituitary grafts had significantly longer latencies to mount (P <0.05) and to intromit (P <0.01) than did the sham-operated controls, while the animals given anterior pituitary grafts differed from the sham-operated controls in latencies to mount (P <0.05) and to intromit (P <0.01), as well as in the number of intromissions (P <0.05). Prolactin-injected animals had significantly reduced intromission rates (P <0.01) and significantly increased latencies to mount (P <0.05) and to intromit (P <0.01) when compared to vehicle-injected controls. Furthermore, the time course of behavioral suppression was similar in oPRL-treated animals to that observed in pars distalis-grafted males, with both groups showing the onset of deficits in sexual activity within 8 to 9 days from the induction of the hyperprolactinemic state. The similarity in pattern and time to onset of behavioral suppression in pituitary-grafted and oPRL-treated animals suggests that behavioral deficits observed in animals with pituitary grafts result from chronic elevation of serum PRL levels.",
author = "Doherty, {Paul C.} and Andrzej Bartke and Smith, {M (Susan)} and Davis, {Steven L.}",
year = "1985",
doi = "10.1016/0018-506X(85)90012-1",
language = "English (US)",
volume = "19",
pages = "111--121",
journal = "Hormones and Behavior",
issn = "0018-506X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Increased serum prolactin levels mediate the suppressive effects of ectopic pituitary grafts on copulatory behavior in male rats

AU - Doherty, Paul C.

AU - Bartke, Andrzej

AU - Smith, M (Susan)

AU - Davis, Steven L.

PY - 1985

Y1 - 1985

N2 - To determine if deficits in sexual activity, observed in pituitary-grafted male rats are due to elevated serum prolactin (PRL) levels found in these animals, the effects of whole pituitary grafts, pars distalis grafts, and ovine (o) PRL treatment on male copulatory behavior were compared. Adult sexually experienced CDF male rats were given four whole pituitary grafts, four pars distalis grafts, or were sham operated. Both groups of grafted animals exhibited suppressed copulatory behavior patterns when tested 18 days after pituitary transplantation. Animals given whole pituitary grafts had significantly longer latencies to mount (P <0.05) and to intromit (P <0.01) than did the sham-operated controls, while the animals given anterior pituitary grafts differed from the sham-operated controls in latencies to mount (P <0.05) and to intromit (P <0.01), as well as in the number of intromissions (P <0.05). Prolactin-injected animals had significantly reduced intromission rates (P <0.01) and significantly increased latencies to mount (P <0.05) and to intromit (P <0.01) when compared to vehicle-injected controls. Furthermore, the time course of behavioral suppression was similar in oPRL-treated animals to that observed in pars distalis-grafted males, with both groups showing the onset of deficits in sexual activity within 8 to 9 days from the induction of the hyperprolactinemic state. The similarity in pattern and time to onset of behavioral suppression in pituitary-grafted and oPRL-treated animals suggests that behavioral deficits observed in animals with pituitary grafts result from chronic elevation of serum PRL levels.

AB - To determine if deficits in sexual activity, observed in pituitary-grafted male rats are due to elevated serum prolactin (PRL) levels found in these animals, the effects of whole pituitary grafts, pars distalis grafts, and ovine (o) PRL treatment on male copulatory behavior were compared. Adult sexually experienced CDF male rats were given four whole pituitary grafts, four pars distalis grafts, or were sham operated. Both groups of grafted animals exhibited suppressed copulatory behavior patterns when tested 18 days after pituitary transplantation. Animals given whole pituitary grafts had significantly longer latencies to mount (P <0.05) and to intromit (P <0.01) than did the sham-operated controls, while the animals given anterior pituitary grafts differed from the sham-operated controls in latencies to mount (P <0.05) and to intromit (P <0.01), as well as in the number of intromissions (P <0.05). Prolactin-injected animals had significantly reduced intromission rates (P <0.01) and significantly increased latencies to mount (P <0.05) and to intromit (P <0.01) when compared to vehicle-injected controls. Furthermore, the time course of behavioral suppression was similar in oPRL-treated animals to that observed in pars distalis-grafted males, with both groups showing the onset of deficits in sexual activity within 8 to 9 days from the induction of the hyperprolactinemic state. The similarity in pattern and time to onset of behavioral suppression in pituitary-grafted and oPRL-treated animals suggests that behavioral deficits observed in animals with pituitary grafts result from chronic elevation of serum PRL levels.

UR - http://www.scopus.com/inward/record.url?scp=0021883890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021883890&partnerID=8YFLogxK

U2 - 10.1016/0018-506X(85)90012-1

DO - 10.1016/0018-506X(85)90012-1

M3 - Article

C2 - 4007795

AN - SCOPUS:0021883890

VL - 19

SP - 111

EP - 121

JO - Hormones and Behavior

JF - Hormones and Behavior

SN - 0018-506X

IS - 2

ER -