Increase in prostaglandin bioavailability precedes the onset of human parturition

Roberto Romero, Hernan Munoz, Ricardo Gomez, Mauro Parra, Max Polanco, Victor Valverde, Jorge Hasbun, Jaime Garrido, Fabio Ghezzi, Moshe Mazor, Jorge Tolosa, Murray D. Mitchell

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The traditional paradigm that prostaglandins (PGs) are of central importance in the initiation of labor has been challenged. A group of investigators has recently reported that the amniotic fluid concentrations of PGE2 and PGF(2α) increase only late in the course of labor implying that 'the accumulation of prostaglandins in amniotic fluid is an after-effect of labor and not indicative of a role of these compounds in the initiation of human parturition'. The present study was conducted to determine whether amniotic fluid prostaglandin concentrations increase prior to the onset of human labor, the central question in this controversy. Three amniocenteses were performed in 17 women with intrahepatic cholestasis of pregnancy - the first two prior to the onset of labor and the third during early spontaneous labor. PGE2 and PGF(2α) were measured with sensitive and specific radioimmunoassays. Amniotic fluid concentrations of PGE2 and PGF(2α) increased prior to the onset of spontaneous labor. An additional increase in the concentrations of PGE2 and PGF(2α) was found in samples obtained in early labor. We conclude that an increase in prostaglandin bioavailability precedes the onset of spontaneous human parturition.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume54
Issue number3
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Prostaglandins F
Amniotic Fluid
Labor Onset
Dinoprostone
Biological Availability
Prostaglandins
Parturition
Personnel
Amniocentesis
Fluids
Radioimmunoassay
Research Personnel

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Romero, R., Munoz, H., Gomez, R., Parra, M., Polanco, M., Valverde, V., ... Mitchell, M. D. (1996). Increase in prostaglandin bioavailability precedes the onset of human parturition. Prostaglandins Leukotrienes and Essential Fatty Acids, 54(3), 187-191. https://doi.org/10.1016/S0952-3278(96)90015-0

Increase in prostaglandin bioavailability precedes the onset of human parturition. / Romero, Roberto; Munoz, Hernan; Gomez, Ricardo; Parra, Mauro; Polanco, Max; Valverde, Victor; Hasbun, Jorge; Garrido, Jaime; Ghezzi, Fabio; Mazor, Moshe; Tolosa, Jorge; Mitchell, Murray D.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 54, No. 3, 1996, p. 187-191.

Research output: Contribution to journalArticle

Romero, R, Munoz, H, Gomez, R, Parra, M, Polanco, M, Valverde, V, Hasbun, J, Garrido, J, Ghezzi, F, Mazor, M, Tolosa, J & Mitchell, MD 1996, 'Increase in prostaglandin bioavailability precedes the onset of human parturition', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 54, no. 3, pp. 187-191. https://doi.org/10.1016/S0952-3278(96)90015-0
Romero, Roberto ; Munoz, Hernan ; Gomez, Ricardo ; Parra, Mauro ; Polanco, Max ; Valverde, Victor ; Hasbun, Jorge ; Garrido, Jaime ; Ghezzi, Fabio ; Mazor, Moshe ; Tolosa, Jorge ; Mitchell, Murray D. / Increase in prostaglandin bioavailability precedes the onset of human parturition. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 1996 ; Vol. 54, No. 3. pp. 187-191.
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