Increase in prostaglandin bioavailability precedes the onset of human parturition

Roberto Romero, Hernan Munoz, Ricardo Gomez, Mauro Parra, Max Polanco, Victor Valverde, Jorge Hasbun, Jaime Garrido, Fabio Ghezzi, Moshe Mazor, Jorge E. Tolosa, Murray D. Mitchell

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

The traditional paradigm that prostaglandins (PGs) are of central importance in the initiation of labor has been challenged. A group of investigators has recently reported that the amniotic fluid concentrations of PGE2 and PGF(2α) increase only late in the course of labor implying that 'the accumulation of prostaglandins in amniotic fluid is an after-effect of labor and not indicative of a role of these compounds in the initiation of human parturition'. The present study was conducted to determine whether amniotic fluid prostaglandin concentrations increase prior to the onset of human labor, the central question in this controversy. Three amniocenteses were performed in 17 women with intrahepatic cholestasis of pregnancy - the first two prior to the onset of labor and the third during early spontaneous labor. PGE2 and PGF(2α) were measured with sensitive and specific radioimmunoassays. Amniotic fluid concentrations of PGE2 and PGF(2α) increased prior to the onset of spontaneous labor. An additional increase in the concentrations of PGE2 and PGF(2α) was found in samples obtained in early labor. We conclude that an increase in prostaglandin bioavailability precedes the onset of spontaneous human parturition.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume54
Issue number3
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'Increase in prostaglandin bioavailability precedes the onset of human parturition'. Together they form a unique fingerprint.

  • Cite this

    Romero, R., Munoz, H., Gomez, R., Parra, M., Polanco, M., Valverde, V., Hasbun, J., Garrido, J., Ghezzi, F., Mazor, M., Tolosa, J. E., & Mitchell, M. D. (1996). Increase in prostaglandin bioavailability precedes the onset of human parturition. Prostaglandins Leukotrienes and Essential Fatty Acids, 54(3), 187-191. https://doi.org/10.1016/S0952-3278(96)90015-0