Incidence of cerebral hemorrhage after antifibrinolytic treatment for embolic stroke in rabbits

P. D. Lyden, K. P. Madden, Wayne Clark, K. C. Sasse, J. A. Zivin

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

We studied thrombolysis in an animal model of embolic stroke to determine the safety of tissue plasminogen activator and streptokinase. We occluded the middle cerebral arteries of 137 rabbits with radiolabeled blood clots and administered tissue plasminogen activator (n=49), streptokinase (n=40), or saline (n=48) at various times after embolization. We assessed the rate of thrombolysis and cerebral hemorrhage 24 hours later. Both drugs were very effective in producing thrombolysis. Compared with saline, streptokinase caused a significant increase in the rate of cerebral hemorrhage (p

Original languageEnglish (US)
Pages (from-to)1589-1593
Number of pages5
JournalStroke
Volume21
Issue number11
StatePublished - 1990
Externally publishedYes

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Keywords

  • Antifibrinolytic agents
  • Cerebral hemorrhage
  • Embolism
  • Rabbits

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Lyden, P. D., Madden, K. P., Clark, W., Sasse, K. C., & Zivin, J. A. (1990). Incidence of cerebral hemorrhage after antifibrinolytic treatment for embolic stroke in rabbits. Stroke, 21(11), 1589-1593.