Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005

Andrew P. Steenhoff; Joshua S. Josephs; Richard M. Rutstein; Kelly A. Gebo; George K. Siberry; Aditya H. Gaur; Robert Warford; P. Todd Korthuis; Stephen A. Spector; Samir S. Shah

doi:10.1097/QAD.0b013e3283440583

Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005

Andrew P. Steenhoff, Joshua S. Josephs, Richard M. Rutstein, Kelly A. Gebo, George K. Siberry, Aditya H. Gaur, Robert Warford, P. Todd Korthuis, Stephen A. Spector, Samir S. Shah

Department of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The incidence of and risk factors for community-acquired pneumonia (CAP) are described from 2000 to 2005 in a multicenter US cohort of HIV-infected children. In 736 patients, 87 episodes of CAP (33.2 events/1000 person-years) had a mean CD4⁺% of 23% (controls: 30%) and mean CD4⁺ cell count of 668 cells/μl (controls: 870 cells/μl). CAP incidence decreased 44% from 2000-2001 to 2002-2005. On multivariate analysis, viral load at least 100 000 copies/ml (odds ratio 3.98; confidence interval 1.05-15.13) was associated with CAP. Herd immunity through pneumococcal immunization may have diluted the effect of individual immunization in this cohort.

Original language	English (US)
Pages (from-to)	717-720
Number of pages	4
Journal	AIDS
Volume	25
Issue number	5
DOIs	https://doi.org/10.1097/QAD.0b013e3283440583
State	Published - Mar 13 2011

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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@article{68d6271ea1224df38e1ed148e200f342,

title = "Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005",

abstract = "The incidence of and risk factors for community-acquired pneumonia (CAP) are described from 2000 to 2005 in a multicenter US cohort of HIV-infected children. In 736 patients, 87 episodes of CAP (33.2 events/1000 person-years) had a mean CD4+% of 23% (controls: 30%) and mean CD4+ cell count of 668 cells/μl (controls: 870 cells/μl). CAP incidence decreased 44% from 2000-2001 to 2002-2005. On multivariate analysis, viral load at least 100 000 copies/ml (odds ratio 3.98; confidence interval 1.05-15.13) was associated with CAP. Herd immunity through pneumococcal immunization may have diluted the effect of individual immunization in this cohort.",

author = "Steenhoff, {Andrew P.} and Josephs, {Joshua S.} and Rutstein, {Richard M.} and Gebo, {Kelly A.} and Siberry, {George K.} and Gaur, {Aditya H.} and Robert Warford and Korthuis, {P. Todd} and Spector, {Stephen A.} and Shah, {Samir S.}",

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T1 - Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005

AU - Steenhoff, Andrew P.

AU - Josephs, Joshua S.

AU - Rutstein, Richard M.

AU - Gebo, Kelly A.

AU - Siberry, George K.

AU - Gaur, Aditya H.

AU - Warford, Robert

AU - Korthuis, P. Todd

AU - Spector, Stephen A.

AU - Shah, Samir S.

PY - 2011/3/13

Y1 - 2011/3/13

N2 - The incidence of and risk factors for community-acquired pneumonia (CAP) are described from 2000 to 2005 in a multicenter US cohort of HIV-infected children. In 736 patients, 87 episodes of CAP (33.2 events/1000 person-years) had a mean CD4+% of 23% (controls: 30%) and mean CD4+ cell count of 668 cells/μl (controls: 870 cells/μl). CAP incidence decreased 44% from 2000-2001 to 2002-2005. On multivariate analysis, viral load at least 100 000 copies/ml (odds ratio 3.98; confidence interval 1.05-15.13) was associated with CAP. Herd immunity through pneumococcal immunization may have diluted the effect of individual immunization in this cohort.

AB - The incidence of and risk factors for community-acquired pneumonia (CAP) are described from 2000 to 2005 in a multicenter US cohort of HIV-infected children. In 736 patients, 87 episodes of CAP (33.2 events/1000 person-years) had a mean CD4+% of 23% (controls: 30%) and mean CD4+ cell count of 668 cells/μl (controls: 870 cells/μl). CAP incidence decreased 44% from 2000-2001 to 2002-2005. On multivariate analysis, viral load at least 100 000 copies/ml (odds ratio 3.98; confidence interval 1.05-15.13) was associated with CAP. Herd immunity through pneumococcal immunization may have diluted the effect of individual immunization in this cohort.

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Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005

Abstract

ASJC Scopus subject areas

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