Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005

Andrew P. Steenhoff, Joshua S. Josephs, Richard M. Rutstein, Kelly A. Gebo, George K. Siberry, Aditya H. Gaur, Robert Warford, Philip (Todd) Korthuis, Stephen A. Spector, Samir S. Shah

Research output: Contribution to journalArticle

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Abstract

The incidence of and risk factors for community-acquired pneumonia (CAP) are described from 2000 to 2005 in a multicenter US cohort of HIV-infected children. In 736 patients, 87 episodes of CAP (33.2 events/1000 person-years) had a mean CD4+% of 23% (controls: 30%) and mean CD4+ cell count of 668 cells/μl (controls: 870 cells/μl). CAP incidence decreased 44% from 2000-2001 to 2002-2005. On multivariate analysis, viral load at least 100 000 copies/ml (odds ratio 3.98; confidence interval 1.05-15.13) was associated with CAP. Herd immunity through pneumococcal immunization may have diluted the effect of individual immunization in this cohort.

Original languageEnglish (US)
Pages (from-to)717-720
Number of pages4
JournalAIDS
Volume25
Issue number5
DOIs
StatePublished - Mar 13 2011

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Pneumonia
HIV
Incidence
Immunization
Herd Immunity
CD4 Lymphocyte Count
Viral Load
Multivariate Analysis
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Steenhoff, A. P., Josephs, J. S., Rutstein, R. M., Gebo, K. A., Siberry, G. K., Gaur, A. H., ... Shah, S. S. (2011). Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005. AIDS, 25(5), 717-720. https://doi.org/10.1097/QAD.0b013e3283440583

Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005. / Steenhoff, Andrew P.; Josephs, Joshua S.; Rutstein, Richard M.; Gebo, Kelly A.; Siberry, George K.; Gaur, Aditya H.; Warford, Robert; Korthuis, Philip (Todd); Spector, Stephen A.; Shah, Samir S.

In: AIDS, Vol. 25, No. 5, 13.03.2011, p. 717-720.

Research output: Contribution to journalArticle

Steenhoff, AP, Josephs, JS, Rutstein, RM, Gebo, KA, Siberry, GK, Gaur, AH, Warford, R, Korthuis, PT, Spector, SA & Shah, SS 2011, 'Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005', AIDS, vol. 25, no. 5, pp. 717-720. https://doi.org/10.1097/QAD.0b013e3283440583
Steenhoff AP, Josephs JS, Rutstein RM, Gebo KA, Siberry GK, Gaur AH et al. Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005. AIDS. 2011 Mar 13;25(5):717-720. https://doi.org/10.1097/QAD.0b013e3283440583
Steenhoff, Andrew P. ; Josephs, Joshua S. ; Rutstein, Richard M. ; Gebo, Kelly A. ; Siberry, George K. ; Gaur, Aditya H. ; Warford, Robert ; Korthuis, Philip (Todd) ; Spector, Stephen A. ; Shah, Samir S. / Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005. In: AIDS. 2011 ; Vol. 25, No. 5. pp. 717-720.
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