Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005

Andrew P. Steenhoff, Joshua S. Josephs, Richard M. Rutstein, Kelly A. Gebo, George K. Siberry, Aditya H. Gaur, Robert Warford, P. Todd Korthuis, Stephen A. Spector, Samir S. Shah

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Abstract

The incidence of and risk factors for community-acquired pneumonia (CAP) are described from 2000 to 2005 in a multicenter US cohort of HIV-infected children. In 736 patients, 87 episodes of CAP (33.2 events/1000 person-years) had a mean CD4+% of 23% (controls: 30%) and mean CD4+ cell count of 668 cells/μl (controls: 870 cells/μl). CAP incidence decreased 44% from 2000-2001 to 2002-2005. On multivariate analysis, viral load at least 100 000 copies/ml (odds ratio 3.98; confidence interval 1.05-15.13) was associated with CAP. Herd immunity through pneumococcal immunization may have diluted the effect of individual immunization in this cohort.

Original languageEnglish (US)
Pages (from-to)717-720
Number of pages4
JournalAIDS
Volume25
Issue number5
DOIs
StatePublished - Mar 13 2011

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Steenhoff, A. P., Josephs, J. S., Rutstein, R. M., Gebo, K. A., Siberry, G. K., Gaur, A. H., Warford, R., Korthuis, P. T., Spector, S. A., & Shah, S. S. (2011). Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005. AIDS, 25(5), 717-720. https://doi.org/10.1097/QAD.0b013e3283440583