In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography

Yimin Wang, Bradley A. Bower, Joseph A. Izatt, Ou Tan, David Huang

Research output: Contribution to journalArticle

183 Scopus citations

Abstract

There is considerable interest in new methods for the assessment of retinal blood flow for the diagnosis of eye diseases. We present in vivo normal human volumetric retinal flow measurement using Fourier domain Doppler optical coherence tomography. We used a dual-plane scanning pattern to determine the angle between the blood flow and the scanning beam in order to measure total flow velocity. Volumetric flow in each blood vessel around the optic nerve head was integrated in one cardiac cycle in each measurement. Measurements were performed in the right eye of one human subject. The measured venous flow velocity ranged from 16.26 mm/ s to 29.7 mm/ s. The arterial flow velocity ranged from 38.35 mm/ s to 51.13 mm/ s. The total retinal venous and arterial flow both added up to approximately 54 μl /min. We believe this is the first demonstration of total retinal blood flow measurement using the OCT technique.

Original languageEnglish (US)
Article number041215
JournalJournal of Biomedical Optics
Volume12
Issue number4
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

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Keywords

  • Blood flow
  • Imaging
  • Optical coherence tomography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry

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