In vivo quantitative whole-brain T1 rho MRI of multiple sclerosis

Jay V. Gonyea, Richard Watts, Angela Applebee, Trevor Andrews, Scott Hipko, Joshua Nickerson, Lindsay Thornton, Christopher G. Filippi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background To apply quantitative whole-brain T1-rho (T) and T2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty-three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age-matched healthy controls were imaged at 3 Tesla. An axial T-weighted three-dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin-lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T2 maps were also acquired. Results Whole brain white matter (WM) T maps were elevated compared with controls (P = 0.002). WM lesion T and T2 values were highly correlated (r = 0.83), but T demonstrated 25% better contrast to noise ratio (P < 0.001). WM lesion T correlated with disease duration. Gray matter T was negatively correlated with the Expanded Disability Status Scale, r = -0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T, but not on T2 (rT1ρ = -0.63, pT1ρ = 0.03; rT2 = -0.17, pT2 = 0.6). Conclusion T MRI demonstrates enhanced lesion contrast compared with T2, and in some cases may provide complementary information. T may provide a useful measure of demyelinating processes in MS.

Original languageEnglish (US)
Pages (from-to)1623-1630
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume42
Issue number6
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

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Multiple Sclerosis
Brain
Relapsing-Remitting Multiple Sclerosis
Process Assessment (Health Care)
Noise
Phenotype
White Matter
Gray Matter

Keywords

  • multiple sclerosis
  • quantitative MRI
  • spin lock
  • T rho
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Gonyea, J. V., Watts, R., Applebee, A., Andrews, T., Hipko, S., Nickerson, J., ... Filippi, C. G. (2015). In vivo quantitative whole-brain T1 rho MRI of multiple sclerosis. Journal of Magnetic Resonance Imaging, 42(6), 1623-1630. https://doi.org/10.1002/jmri.24954

In vivo quantitative whole-brain T1 rho MRI of multiple sclerosis. / Gonyea, Jay V.; Watts, Richard; Applebee, Angela; Andrews, Trevor; Hipko, Scott; Nickerson, Joshua; Thornton, Lindsay; Filippi, Christopher G.

In: Journal of Magnetic Resonance Imaging, Vol. 42, No. 6, 01.12.2015, p. 1623-1630.

Research output: Contribution to journalArticle

Gonyea, JV, Watts, R, Applebee, A, Andrews, T, Hipko, S, Nickerson, J, Thornton, L & Filippi, CG 2015, 'In vivo quantitative whole-brain T1 rho MRI of multiple sclerosis', Journal of Magnetic Resonance Imaging, vol. 42, no. 6, pp. 1623-1630. https://doi.org/10.1002/jmri.24954
Gonyea, Jay V. ; Watts, Richard ; Applebee, Angela ; Andrews, Trevor ; Hipko, Scott ; Nickerson, Joshua ; Thornton, Lindsay ; Filippi, Christopher G. / In vivo quantitative whole-brain T1 rho MRI of multiple sclerosis. In: Journal of Magnetic Resonance Imaging. 2015 ; Vol. 42, No. 6. pp. 1623-1630.
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abstract = "Background To apply quantitative whole-brain T1-rho (T1ρ) and T2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty-three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age-matched healthy controls were imaged at 3 Tesla. An axial T1ρ-weighted three-dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin-lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T2 maps were also acquired. Results Whole brain white matter (WM) T1ρ maps were elevated compared with controls (P = 0.002). WM lesion T1ρ and T2 values were highly correlated (r = 0.83), but T1ρ demonstrated 25{\%} better contrast to noise ratio (P < 0.001). WM lesion T1ρ correlated with disease duration. Gray matter T1ρ was negatively correlated with the Expanded Disability Status Scale, r = -0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T1ρ, but not on T2 (rT1ρ = -0.63, pT1ρ = 0.03; rT2 = -0.17, pT2 = 0.6). Conclusion T1ρ MRI demonstrates enhanced lesion contrast compared with T2, and in some cases may provide complementary information. T1ρ may provide a useful measure of demyelinating processes in MS.",
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AU - Nickerson, Joshua

AU - Thornton, Lindsay

AU - Filippi, Christopher G.

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N2 - Background To apply quantitative whole-brain T1-rho (T1ρ) and T2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty-three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age-matched healthy controls were imaged at 3 Tesla. An axial T1ρ-weighted three-dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin-lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T2 maps were also acquired. Results Whole brain white matter (WM) T1ρ maps were elevated compared with controls (P = 0.002). WM lesion T1ρ and T2 values were highly correlated (r = 0.83), but T1ρ demonstrated 25% better contrast to noise ratio (P < 0.001). WM lesion T1ρ correlated with disease duration. Gray matter T1ρ was negatively correlated with the Expanded Disability Status Scale, r = -0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T1ρ, but not on T2 (rT1ρ = -0.63, pT1ρ = 0.03; rT2 = -0.17, pT2 = 0.6). Conclusion T1ρ MRI demonstrates enhanced lesion contrast compared with T2, and in some cases may provide complementary information. T1ρ may provide a useful measure of demyelinating processes in MS.

AB - Background To apply quantitative whole-brain T1-rho (T1ρ) and T2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty-three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age-matched healthy controls were imaged at 3 Tesla. An axial T1ρ-weighted three-dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin-lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T2 maps were also acquired. Results Whole brain white matter (WM) T1ρ maps were elevated compared with controls (P = 0.002). WM lesion T1ρ and T2 values were highly correlated (r = 0.83), but T1ρ demonstrated 25% better contrast to noise ratio (P < 0.001). WM lesion T1ρ correlated with disease duration. Gray matter T1ρ was negatively correlated with the Expanded Disability Status Scale, r = -0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T1ρ, but not on T2 (rT1ρ = -0.63, pT1ρ = 0.03; rT2 = -0.17, pT2 = 0.6). Conclusion T1ρ MRI demonstrates enhanced lesion contrast compared with T2, and in some cases may provide complementary information. T1ρ may provide a useful measure of demyelinating processes in MS.

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