In vitro malignant transformation of hamster retina by herpes simplex virus

Daniel Albert, J. J. Papale, P. Strumph, G. A. Fournier

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hamster retina was infected in vitro with irradiated herpes simplex virus type 2. Cells underwent malignant transformation, and when injected subcutaneously into nude mice and hamsters, produced transferable tumors. Transformed cells were found to have HSV antigen as determined by indirect fluorescent staining. In addition, the undifferentiated transformed retinal cells possess neurosecretory granules and retinoic acid receptors and produce growth factor, features similar to those found in spontaneous human retinoblastoma. This is the first neoplasm of ocular tissues induced experimentally by herpes simplex virus (HSV).

Original languageEnglish (US)
Pages (from-to)1489-1495
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume24
Issue number11
StatePublished - Dec 1 1983
Externally publishedYes

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Simplexvirus
Cricetinae
Retina
Retinoic Acid Receptors
Human Herpesvirus 2
Retinoblastoma
Nude Mice
Neoplasms
Intercellular Signaling Peptides and Proteins
Staining and Labeling
Antigens
In Vitro Techniques

ASJC Scopus subject areas

  • Ophthalmology

Cite this

In vitro malignant transformation of hamster retina by herpes simplex virus. / Albert, Daniel; Papale, J. J.; Strumph, P.; Fournier, G. A.

In: Investigative Ophthalmology and Visual Science, Vol. 24, No. 11, 01.12.1983, p. 1489-1495.

Research output: Contribution to journalArticle

Albert, Daniel ; Papale, J. J. ; Strumph, P. ; Fournier, G. A. / In vitro malignant transformation of hamster retina by herpes simplex virus. In: Investigative Ophthalmology and Visual Science. 1983 ; Vol. 24, No. 11. pp. 1489-1495.
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